This review is intended to discuss recent developments in the molecular pharmacology of the all adrenergic receptor (α1-AR) subtypes. After a brief historical development, we will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cloning, nomenclature, signalling mechanisms, and genomic organization of the α1-AR subtypes. We will also highlight recent mutational studies that identify key amino acid residues involved in ligand binding, as well as the role of the α1-AR subtypes in regulating physiologic processes.
|Number of pages||11|
|State||Published - Aug 1996|
Bibliographical noteFunding Information:
We thank Erika M. Schosser and Stephanie E. Edelmann fi~r critical reading of the manuscript. The research in our laboratories is supported by grants from the National Institutes of Health (HL-38120 to M. T. P. and NS-19583 to D. M. P.).
- α-adrenergic receptors
ASJC Scopus subject areas
- Cell Biology