Recent advances in the molecular pharmacology of the α1-adrenergic receptors

Richard D. Guarino, Dianne M. Perez, Michael T. Piascik

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


This review is intended to discuss recent developments in the molecular pharmacology of the all adrenergic receptor (α1-AR) subtypes. After a brief historical development, we will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cloning, nomenclature, signalling mechanisms, and genomic organization of the α1-AR subtypes. We will also highlight recent mutational studies that identify key amino acid residues involved in ligand binding, as well as the role of the α1-AR subtypes in regulating physiologic processes.

Original languageEnglish
Pages (from-to)323-333
Number of pages11
JournalCellular Signalling
Issue number5
StatePublished - Aug 1996

Bibliographical note

Funding Information:
We thank Erika M. Schosser and Stephanie E. Edelmann fi~r critical reading of the manuscript. The research in our laboratories is supported by grants from the National Institutes of Health (HL-38120 to M. T. P. and NS-19583 to D. M. P.).


  • Review
  • α-adrenergic receptors

ASJC Scopus subject areas

  • Cell Biology


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