Recent Progress in Juvenile Hormone Analogs (JHA) Research

Parthasarathy Ramaseshadri, Robert Farkaš, Subba Reddy Palli

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

39 Scopus citations


Insect juvenile hormones (JHs) are important regulators of development and reproduction. Perturbation in the homeostasis at inappropriate times in the various developmental and reproductive stages of an insect, which normally requires controlled release and metabolism of this and other hormones, results in abnormal development or lethal consequences. Such deliberate consequences have been possible by the discovery and use of Juvenile Hormone Analogs (JHAs), the synthetic chemicals that mimic JH action, which have also been utilised as insecticides for several decades. With the availability of molecular tools and improvement in pharmacophore analyses in the recent years, there has been considerable advancement in the understanding of the mode of action of JHAs and development of methods for discovery of novel JHAs. Although there is limited use of JHAs for insect pest control, the list of new insect species susceptible to these compounds has been expanding revealing the potential for future use of this class of insecticides. The relatively fewer effects of JHAs on non-target insects and animals and favourable environmental fate of these compounds make them attractive insecticides for inclusion in integrated pest management programmes. In this review, we provide a comprehensive overview of JHAs, as endocrinological and insecticidal tools covering all the relevant research topics on JHAs research during the past three decades.

Original languageEnglish
Title of host publicationAdvances in Insect Physiology
Number of pages84
StatePublished - 2012

Publication series

NameAdvances in Insect Physiology
ISSN (Print)0065-2806

Bibliographical note

Funding Information:
We would like to thank Denisa Beňová-Liszeková and Milan Beňo for their active involvement in these studies and skillful help in preparing this manuscript. R.F. also thanks Karel Sláma, František Sehnal, Clive A. Henrick, William S. Bowers, Hans Laufer, Lawrence I. Gilbert, Zdeněk Wimmer, and Martin Rejzek for providing many of the JH compounds for testing. The research in SRP laboratory was supported by the National Science Foundation (IBN-0421856), the National Institute of Health (GM070559-08), and the National Research Initiative of the USDA-NIFA (2011-67013-30143). The work in R.F. lab was supported by VEGA grants 2/999533, 2/7194/20 and 2/3025/23, and 2/0170/10, APVT-51-027402 grant, by NATO grants CRG-972173 and LST.CLG-977559, and EEA-Norwegian FM SK-0086 grant. This report is contribution number 11-08-075 from the Kentucky Agricultural Experimental Station.


  • Hydroprene
  • Met
  • Methoprene
  • Methoprene tolerant
  • Molecular modelling
  • Pyriproxyfen
  • Resistance

ASJC Scopus subject areas

  • Insect Science


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