Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain

Isaac Colvett; Anah Gilmore; Samuel Guzman; Aurélie Ledreux; Jorge E. Quintero; Dhanunjaya Rao Ginjupally; Julie A. Gurwell; John T. Slevin; Zain Guduru; Greg A. Gerhardt; Craig G. van Horne; Ann Charlotte Granholm

doi:10.3390/jcm12196121

Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain

Isaac Colvett, Anah Gilmore, Samuel Guzman, Aurélie Ledreux, Jorge E. Quintero, Dhanunjaya Rao Ginjupally, Julie A. Gurwell, John T. Slevin, Zain Guduru, Greg A. Gerhardt, Craig G. van Horne, Ann Charlotte Granholm

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Parkinson’s disease (PD) is a severe neurological disease for which there is no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of Meynert (NBM) or the midbrain substantia nigra (SN). The grafts did not exhibit significant cell death or severe host-tissue reaction up to 55 months post-grafting and contained peripheral cells. Dopaminergic neurites showed active growth in the graft area and into the graft in the SN graft, and cholinergic neurites were abundant near the graft in the NBM. These results provide a histological basis for changes in clinical features after autologous peripheral nerve tissue grafting into the NBM or SN in PD.

Original language	English
Article number	6121
Journal	Journal of Clinical Medicine
Volume	12
Issue number	19
DOIs	https://doi.org/10.3390/jcm12196121
State	Published - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Funding

This work was supported by the Ann Hanley Neuroscience Fund, the UK College of Medicine BRAIN Alliance, and the National Center for Advancing Translational Sciences through NIH grant UL1TR001998.

Funders	Funder number
Ann Hanley Neuroscience Fund
UK College of Medicine BRAIN Alliance
National Institutes of Health (NIH)	UL1TR001998
National Center for Advancing Translational Sciences (NCATS)

Keywords

Parkinson’s disease
neurodegenerative disorders
nucleus basalis of Meynert
substantia nigra

ASJC Scopus subject areas

General Medicine

Access to Document

10.3390/jcm12196121

Cite this

Colvett, I., Gilmore, A., Guzman, S., Ledreux, A., Quintero, J. E., Ginjupally, D. R., Gurwell, J. A., Slevin, J. T., Guduru, Z., Gerhardt, G. A., van Horne, C. G., & Granholm, A. C. (2023). Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. Journal of Clinical Medicine, 12(19), Article 6121. https://doi.org/10.3390/jcm12196121

@article{37c97a5ffdd54a52bb95957a8654bb58,

title = "Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain",

abstract = "Parkinson{\textquoteright}s disease (PD) is a severe neurological disease for which there is no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of Meynert (NBM) or the midbrain substantia nigra (SN). The grafts did not exhibit significant cell death or severe host-tissue reaction up to 55 months post-grafting and contained peripheral cells. Dopaminergic neurites showed active growth in the graft area and into the graft in the SN graft, and cholinergic neurites were abundant near the graft in the NBM. These results provide a histological basis for changes in clinical features after autologous peripheral nerve tissue grafting into the NBM or SN in PD.",

keywords = "Parkinson{\textquoteright}s disease, neurodegenerative disorders, nucleus basalis of Meynert, substantia nigra",

author = "Isaac Colvett and Anah Gilmore and Samuel Guzman and Aur{\'e}lie Ledreux and Quintero, {Jorge E.} and Ginjupally, {Dhanunjaya Rao} and Gurwell, {Julie A.} and Slevin, {John T.} and Zain Guduru and Gerhardt, {Greg A.} and {van Horne}, {Craig G.} and Granholm, {Ann Charlotte}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = oct,

doi = "10.3390/jcm12196121",

language = "English",

volume = "12",

number = "19",

}

TY - JOUR

T1 - Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain

AU - Colvett, Isaac

AU - Gilmore, Anah

AU - Guzman, Samuel

AU - Ledreux, Aurélie

AU - Quintero, Jorge E.

AU - Ginjupally, Dhanunjaya Rao

AU - Gurwell, Julie A.

AU - Slevin, John T.

AU - Guduru, Zain

AU - Gerhardt, Greg A.

AU - van Horne, Craig G.

AU - Granholm, Ann Charlotte

PY - 2023/10

Y1 - 2023/10

N2 - Parkinson’s disease (PD) is a severe neurological disease for which there is no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of Meynert (NBM) or the midbrain substantia nigra (SN). The grafts did not exhibit significant cell death or severe host-tissue reaction up to 55 months post-grafting and contained peripheral cells. Dopaminergic neurites showed active growth in the graft area and into the graft in the SN graft, and cholinergic neurites were abundant near the graft in the NBM. These results provide a histological basis for changes in clinical features after autologous peripheral nerve tissue grafting into the NBM or SN in PD.

AB - Parkinson’s disease (PD) is a severe neurological disease for which there is no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of Meynert (NBM) or the midbrain substantia nigra (SN). The grafts did not exhibit significant cell death or severe host-tissue reaction up to 55 months post-grafting and contained peripheral cells. Dopaminergic neurites showed active growth in the graft area and into the graft in the SN graft, and cholinergic neurites were abundant near the graft in the NBM. These results provide a histological basis for changes in clinical features after autologous peripheral nerve tissue grafting into the NBM or SN in PD.

KW - Parkinson’s disease

KW - neurodegenerative disorders

KW - nucleus basalis of Meynert

KW - substantia nigra

UR - http://www.scopus.com/inward/record.url?scp=85173887993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85173887993&partnerID=8YFLogxK

U2 - 10.3390/jcm12196121

DO - 10.3390/jcm12196121

M3 - Article

AN - SCOPUS:85173887993

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 19

M1 - 6121

ER -

Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this