Recombinant human TNF(a) stimulates production of granulocyte colony-stimulating factor

H. P. Koeffler; J. Gasson; J. Ranyard; L. Souza; M. Shepard; R. Munker

doi:10.1182/blood.v70.1.55.55

Recombinant human TNF(a) stimulates production of granulocyte colony-stimulating factor

H. P. Koeffler
, J. Gasson
, J. Ranyard
, L. Souza
, M. Shepard
, R. Munker

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

Tumor necrosis factor a (TNF(a)) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF(ß) is at least 1,000-fold less potent than TNF(a) in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF(a) to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Blood
Volume	70
Issue number	1
DOIs	https://doi.org/10.1182/blood.v70.1.55.55
State	Published - 1987

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R01CA033936

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v70.1.55.55

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title = "Recombinant human TNF(a) stimulates production of granulocyte colony-stimulating factor",

abstract = "Tumor necrosis factor a (TNF(a)) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF({\ss}) is at least 1,000-fold less potent than TNF(a) in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF(a) to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.",

author = "Koeffler, \{H. P.\} and J. Gasson and J. Ranyard and L. Souza and M. Shepard and R. Munker",

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language = "English",

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T1 - Recombinant human TNF(a) stimulates production of granulocyte colony-stimulating factor

AU - Koeffler, H. P.

AU - Gasson, J.

AU - Ranyard, J.

AU - Souza, L.

AU - Shepard, M.

AU - Munker, R.

PY - 1987

Y1 - 1987

N2 - Tumor necrosis factor a (TNF(a)) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF(ß) is at least 1,000-fold less potent than TNF(a) in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF(a) to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.

AB - Tumor necrosis factor a (TNF(a)) stimulates production of granulocyte colony-stimulating factor (G-CSF) protein and mRNA in fibroblast cells. In contrast, TNF(ß) is at least 1,000-fold less potent than TNF(a) in increasing levels of G-CSF and GM-CSF activity and mRNA. The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after exposure to TNF. The ability of TNF(a) to stimulate production of CSF in fibroblasts may be pivotal to regulation of hematopoiesis.

UR - https://www.scopus.com/pages/publications/0023272408

UR - https://www.scopus.com/pages/publications/0023272408#tab=citedBy

U2 - 10.1182/blood.v70.1.55.55

DO - 10.1182/blood.v70.1.55.55

M3 - Article

C2 - 2439155

AN - SCOPUS:0023272408

SN - 0006-4971

VL - 70

SP - 55

EP - 59

JO - Blood

JF - Blood

IS - 1

ER -

Recombinant human TNF(a) stimulates production of granulocyte colony-stimulating factor

Abstract

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ASJC Scopus subject areas

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