TY - JOUR
T1 - Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies
T2 - A Scientific Statement from the American Heart Association
AU - Daugherty, Alan
AU - Tall, Alan R.
AU - Daemen, Mat J.A.P.
AU - Falk, Erling
AU - Fisher, Edward A.
AU - García-Cardeña, Guillermo
AU - Lusis, Aldons J.
AU - Owens, A. Phillip
AU - Rosenfeld, Michael E.
AU - Virmani, Renu
N1 - Publisher Copyright:
© 2017 American Heart Association, Inc.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies. Recommendations include the following: (1) animal model selection, with commentary on the fidelity of mimicking facets of the human disease; (2) experimental design and its impact on the interpretation of data; and (3) standard methods to enhance accuracy of measurements and characterization of atherosclerotic lesions.
AB - Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies. Recommendations include the following: (1) animal model selection, with commentary on the fidelity of mimicking facets of the human disease; (2) experimental design and its impact on the interpretation of data; and (3) standard methods to enhance accuracy of measurements and characterization of atherosclerotic lesions.
KW - AHA Scientific Statements
KW - animal models
KW - atherosclerosis
KW - cholesterol
KW - histology
KW - pathology
UR - http://www.scopus.com/inward/record.url?scp=85025443586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025443586&partnerID=8YFLogxK
U2 - 10.1161/ATV.0000000000000062
DO - 10.1161/ATV.0000000000000062
M3 - Article
C2 - 28729366
AN - SCOPUS:85025443586
SN - 1079-5642
VL - 37
SP - e131-e157
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 9
ER -