Abstract
Spinal cord injury (SCI) results in devastating cardiovascular dysfunction. Noxious stimuli from the rectum during bowel routine often trigger life-threatening blood pressure surges, termed autonomic dysreflexia (AD). Rectal application of anesthetic lidocaine jelly has been recommended during bowel care to reduce AD severity by mitigating sensory input. However, clinical studies have reported contradicting evidence. We performed a pre-clinical study on the efficacy of rectal lidocaine in a standardized rodent T3 transection model. We found that 2% and 10% lidocaine significantly reduced AD severity by 32% and 50%, respectively, compared with control (p < 0.0001). Our pre-clinical experiments support the current recommendation of rectal lidocaine application during bowel care.
| Original language | English |
|---|---|
| Pages (from-to) | 1764-1768 |
| Number of pages | 5 |
| Journal | Journal of Neurotrauma |
| Volume | 39 |
| Issue number | 23-24 |
| DOIs | |
| State | Published - Dec 1 2022 |
Bibliographical note
Publisher Copyright:© Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.
Funding
This study was supported by Seed grants from the International Collaboration on Repair Discoveries (ICORD). The equipment for the study was supported by CFI/BDNF (#35869, PI Dr. Krassioukov). Ms. Kalimullina is supported by the Canadian Institutes of Health Research (CIHR) Canada Graduate Scholarship—Master's. Dr. Sachdeva is supported by the Wings for Life Spinal Cord Research Foundation (AWD-018048). Dr. Krassioukov holds the Endowed Chair in Rehabilitation Medicine.
| Funders | Funder number |
|---|---|
| BDNF | 35869 |
| Wings for Life Spinal Cord Research Foundation | AWD-018048 |
| Canadian Institutes of Health Research | |
| Canada Foundation for Innovation |
Keywords
- autonomic dysreflexia
- bowel management
- lidocaine
- spinal cord injury
ASJC Scopus subject areas
- Clinical Neurology