Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

Nathalie M. Pinkerton; Céline Frongia; Valérie Lobjois; Brian K. Wilson; Matthew J. Bruzek; Robert K. Prud'Homme; John Anthony; Frédéric Bolze; Stefan Chassaing

doi:10.1039/c6ra09954h

Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

Nathalie M. Pinkerton, Céline Frongia, Valérie Lobjois, Brian K. Wilson, Matthew J. Bruzek, Robert K. Prud'Homme, John Anthony, Frédéric Bolze, Stefan Chassaing

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Biocompatible and biostable EtTP-5-loaded organic core-shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

Original language	English
Pages (from-to)	65770-65774
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	70
DOIs	https://doi.org/10.1039/c6ra09954h
State	Published - 2016

Bibliographical note

Publisher Copyright:
This journal is © The Royal Society of Chemistry 2016.

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c6ra09954h

Cite this

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title = "Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models",

abstract = "Biocompatible and biostable EtTP-5-loaded organic core-shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.",

author = "Pinkerton, \{Nathalie M.\} and C{\'e}line Frongia and Val{\'e}rie Lobjois and Wilson, \{Brian K.\} and Bruzek, \{Matthew J.\} and Prud'Homme, \{Robert K.\} and John Anthony and Fr{\'e}d{\'e}ric Bolze and Stefan Chassaing",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6ra09954h",

language = "English",

volume = "6",

pages = "65770--65774",

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TY - JOUR

T1 - Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

AU - Pinkerton, Nathalie M.

AU - Frongia, Céline

AU - Lobjois, Valérie

AU - Wilson, Brian K.

AU - Bruzek, Matthew J.

AU - Prud'Homme, Robert K.

AU - Anthony, John

AU - Bolze, Frédéric

AU - Chassaing, Stefan

PY - 2016

Y1 - 2016

N2 - Biocompatible and biostable EtTP-5-loaded organic core-shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

AB - Biocompatible and biostable EtTP-5-loaded organic core-shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

UR - https://www.scopus.com/pages/publications/84978483981

UR - https://www.scopus.com/inward/citedby.url?scp=84978483981&partnerID=8YFLogxK

U2 - 10.1039/c6ra09954h

DO - 10.1039/c6ra09954h

M3 - Article

AN - SCOPUS:84978483981

SN - 2046-2069

VL - 6

SP - 65770

EP - 65774

JO - RSC Advances

JF - RSC Advances

IS - 70

ER -

Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

Abstract

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ASJC Scopus subject areas

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