Redistribution of synaptic vesicles during long-term potentiation in the hippocampus

Michael D. Applegate, Douglas S. Kerr, Philip W. Landfield

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Synaptic vesicles were quantified 20 min after the induction of long-term potentiation (LTP) in the Schaffer-commissural system of the hippocampus. With LTP, significant increases were found in vesicles attached to the active zone membrane, and in the percentage of vesicles adjacent to the active zone. In addition, as others have reported, overall vesicle density was decreased and spine area was increased. These results suggest that an increased probability of vesicle may contribute to brain LTP.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalBrain Research
Issue number2
StatePublished - Jan 20 1987


  • Dendritic spine
  • Hippocampus
  • Long-term potentiation
  • Presynaptic
  • Stereology
  • Synaptic vesicle

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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