Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: Insights into the progression of this dementing disorder

D. Allan Butterfield, Rukhsana Sultana

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Alzheimer disease is a common age-related neurodegenerative disease characterized pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and progressive neuronal deficits. The senile plaques contain amyloid-β (1-42) and amyloid-β (1-40), that has been shown by a number of laboratories to induce oxidative stress and as well as neurodegeneration, although the exact mechanisms remained to be defined. Our laboratory showed an increased oxidative stress in AD and MCI brain as indexed by protein oxidation and lipid peroxidation. In the present review, we summarize our finding of oxidatively modified proteins using a redox proteomics approach in AD and MCI brain to investigate the mechanism that may be involved in MCI and AD pathogenesis and discuss our findings in terms of AD progression and pathogenesis.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalJournal of Alzheimer's Disease
Volume12
Issue number1
DOIs
StatePublished - 2007

Keywords

  • Alzheimer's disease
  • Amyloid
  • Mild cognitive impairment
  • Oxidative stress
  • Redox proteomics

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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