Abstract
The misexpression as well as a knock down of the 5-HT2dro receptor produces slower body movements in larvae and altered development. When 1 st instar larvae are raised with altered expression levels a high degree of death occurred. Exposure of the CNS to 5-HT in control larva increases motor unit excitability; however, when the 5-HT2dro expression is decreased the relative sensitivity to exogenously applied 5-HT is enhanced. This is likely a function of reduced basal CNS activity in this line. No change was observed for the strain with an over-expression compared to controls. Evoked sensory-CNS-motor circuits as well as spontaneous motor neuronal activity are also reduced. Like CNS activity, Heart Rate (HR) in larva is sensitive to 5-HT. When the 1 st instar to early 3rd instar were chronically reduced or misexpressed in the 5-HT receptor no alteration to 5-HT sensitivity on HR occurred, although the initial HR was lower in both strains as compared to wild type. Thus, a normal expression of the 5-HT2dro is required for development and CNS responsiveness to 5-HT, but this receptor subtype might not function in acute responsiveness of the heart to 5-HT, although the receptor has some effect on basal heart rate.
Original language | English |
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Pages (from-to) | 101-114 |
Number of pages | 14 |
Journal | International Journal of Zoological Research |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - 2009 |
Keywords
- CNS
- Heat shock
- Neural circuit
- Synapse
ASJC Scopus subject areas
- Animal Science and Zoology