TY - JOUR
T1 - Reduced Coronary Vasodilator Function after Myocardial Infarction
AU - Bauer, John Anthony
AU - Uren, Neal G.
AU - Lefroy, David C.
AU - Crake, Tom
PY - 1994/12/8
Y1 - 1994/12/8
N2 - To the Editor: Uren et al. (July 28 issue)1 conclude that the coronary vasodilator response is severely impaired after myocardial infarction, in both infarcted and uninfarcted myocardial regions. However, the results of their studies are complicated by other important changes that occur during and after myocardial infarction, which were not considered. Dipyridamole is a basic, lipophilic drug that is extensively and avidly bound to serum protein and has a relatively high rate of clearance.2 At relevant concentrations, over 99 percent of dipyridamole is bound to α1-acid glycoprotein.2 Myocardial infarction causes dramatic (over twofold) time-dependent increases in the concentrations of this…
AB - To the Editor: Uren et al. (July 28 issue)1 conclude that the coronary vasodilator response is severely impaired after myocardial infarction, in both infarcted and uninfarcted myocardial regions. However, the results of their studies are complicated by other important changes that occur during and after myocardial infarction, which were not considered. Dipyridamole is a basic, lipophilic drug that is extensively and avidly bound to serum protein and has a relatively high rate of clearance.2 At relevant concentrations, over 99 percent of dipyridamole is bound to α1-acid glycoprotein.2 Myocardial infarction causes dramatic (over twofold) time-dependent increases in the concentrations of this…
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U2 - 10.1056/NEJM199412083312313
DO - 10.1056/NEJM199412083312313
M3 - Letter
C2 - 7969335
AN - SCOPUS:0028135027
SN - 0028-4793
VL - 331
SP - 1590
EP - 1591
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 23
ER -