Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson's disease, but not Parkinson plus patients, from an Indian population

Merina Varghese; Mritunjay Pandey; Ananda Samanta; Prasanta Kumar Gangopadhyay; Kochupurackal P. Mohanakumar

doi:10.1016/j.jns.2008.12.021

Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson's disease, but not Parkinson plus patients, from an Indian population

Merina Varghese
, Mritunjay Pandey
, Ananda Samanta
, Prasanta Kumar Gangopadhyay
, Kochupurackal P. Mohanakumar

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The observation of decline in mitochondrial electron transport chain function, specifically at complex I, in patients with Parkinson's disease (PD) has been reported by several groups. This study investigates whether a defect of mitochondrial function is present in the platelets of PD patients from an Indian population. We found that the NADH dehydrogenase activity in the platelets of PD patients is lower than that in healthy age- and gender-matched controls, while the succinate dehydrogenase activity was similar in both groups. Furthermore, there was no change in either of the activities in patients with Parkinson plus syndrome or atypical parkinsonism. This is the first report indicating a decline in mitochondrial function in the platelets of PD patients from the Indian population, offering further support to the role of a mitochondrial defect in PD.

Original language	English
Pages (from-to)	39-42
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	279
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2008.12.021
State	Published - Apr 15 2009

Funding

This study was supported by funding from the Council of Scientific and Industrial Research (CSIR), Government of India under the networking program of Cell and Tissue Engineering (CMM-002) of the tenth five-year plan, and the Supra-institutional Project in IICB, under the eleventh Five Year Plan. MV and MP received Junior & Senior Research Fellowships from CSIR.

Funders	Funder number
Bangladesh Council of Scientific and Industrial Research	CMM-002

Keywords

Electron transport chain
Mitochondria
NADH dehydrogenase
Parkinsonism
Platelets
Succinate dehydrogenase

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2008.12.021

Cite this

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abstract = "The observation of decline in mitochondrial electron transport chain function, specifically at complex I, in patients with Parkinson's disease (PD) has been reported by several groups. This study investigates whether a defect of mitochondrial function is present in the platelets of PD patients from an Indian population. We found that the NADH dehydrogenase activity in the platelets of PD patients is lower than that in healthy age- and gender-matched controls, while the succinate dehydrogenase activity was similar in both groups. Furthermore, there was no change in either of the activities in patients with Parkinson plus syndrome or atypical parkinsonism. This is the first report indicating a decline in mitochondrial function in the platelets of PD patients from the Indian population, offering further support to the role of a mitochondrial defect in PD.",

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AU - Samanta, Ananda

AU - Gangopadhyay, Prasanta Kumar

AU - Mohanakumar, Kochupurackal P.

PY - 2009/4/15

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N2 - The observation of decline in mitochondrial electron transport chain function, specifically at complex I, in patients with Parkinson's disease (PD) has been reported by several groups. This study investigates whether a defect of mitochondrial function is present in the platelets of PD patients from an Indian population. We found that the NADH dehydrogenase activity in the platelets of PD patients is lower than that in healthy age- and gender-matched controls, while the succinate dehydrogenase activity was similar in both groups. Furthermore, there was no change in either of the activities in patients with Parkinson plus syndrome or atypical parkinsonism. This is the first report indicating a decline in mitochondrial function in the platelets of PD patients from the Indian population, offering further support to the role of a mitochondrial defect in PD.

AB - The observation of decline in mitochondrial electron transport chain function, specifically at complex I, in patients with Parkinson's disease (PD) has been reported by several groups. This study investigates whether a defect of mitochondrial function is present in the platelets of PD patients from an Indian population. We found that the NADH dehydrogenase activity in the platelets of PD patients is lower than that in healthy age- and gender-matched controls, while the succinate dehydrogenase activity was similar in both groups. Furthermore, there was no change in either of the activities in patients with Parkinson plus syndrome or atypical parkinsonism. This is the first report indicating a decline in mitochondrial function in the platelets of PD patients from the Indian population, offering further support to the role of a mitochondrial defect in PD.

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KW - Mitochondria

KW - NADH dehydrogenase

KW - Parkinsonism

KW - Platelets

KW - Succinate dehydrogenase

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Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson's disease, but not Parkinson plus patients, from an Indian population

Abstract

Funding

Keywords

ASJC Scopus subject areas

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