TY - JOUR
T1 - Reduction of carcinogenic chromium(VI) on the skin of living rats
AU - Liu, Ke Jian
AU - Mäder, Karsten
AU - Shi, Xianglin
AU - Swartz, Harold M.
PY - 1997/10
Y1 - 1997/10
N2 - The reduction of chromate (Cr(VI)) on the skin of living rats was investigated using the technique of in vivo electron para-magnetic resonance (EPR) spectroscopy with a surface coil resonator. Topical application of aqueous solution of Cr(VI) on the skin of rats generated the transient species, Cr(V). Partial removal of the stratum corneum increased the rates of formation and decay of Cr(V), as well as Cr(V) signal intensity. The results demonstrate that skin represents one route for chromium to enter into animals and humans. The generation of reactive Cr(V) species in the reduction of Cr(VI) by the skin may play an important role in the mechanism of Cr(VI)- induced skin cancer. These findings indicate the potential for in vivo EPR spectroscopy for studying the metabolism of para-magnetic reactive species in chemical and biochemical reactions occurring in/on the skin of both small and large animals, and possibly humans.
AB - The reduction of chromate (Cr(VI)) on the skin of living rats was investigated using the technique of in vivo electron para-magnetic resonance (EPR) spectroscopy with a surface coil resonator. Topical application of aqueous solution of Cr(VI) on the skin of rats generated the transient species, Cr(V). Partial removal of the stratum corneum increased the rates of formation and decay of Cr(V), as well as Cr(V) signal intensity. The results demonstrate that skin represents one route for chromium to enter into animals and humans. The generation of reactive Cr(V) species in the reduction of Cr(VI) by the skin may play an important role in the mechanism of Cr(VI)- induced skin cancer. These findings indicate the potential for in vivo EPR spectroscopy for studying the metabolism of para-magnetic reactive species in chemical and biochemical reactions occurring in/on the skin of both small and large animals, and possibly humans.
KW - Chromium
KW - In vivo EPR
KW - Skin
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U2 - 10.1002/mrm.1910380403
DO - 10.1002/mrm.1910380403
M3 - Article
C2 - 9324316
AN - SCOPUS:0004729686
SN - 0740-3194
VL - 38
SP - 524
EP - 526
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 4
ER -
