Abstract
Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) freeradical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'deoxyguanosine, and activation of nuclear transcription factor B.
Original language | English |
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Pages (from-to) | 87-104 |
Number of pages | 18 |
Journal | Journal of Toxicology and Environmental Health - Part B: Critical Reviews |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1999 |
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis