Reduction of chromium (vi) and its relationship to carcinogenesis

Xianglin Shi, Arthur Chiu, Chia Ting Chen, Barry Halliwell, Vince Castranova, Val Vallyathan

Research output: Contribution to journalArticlepeer-review

298 Scopus citations


Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) freeradical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'deoxyguanosine, and activation of nuclear transcription factor B.

Original languageEnglish
Pages (from-to)87-104
Number of pages18
JournalJournal of Toxicology and Environmental Health - Part B: Critical Reviews
Issue number1
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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