TY - JOUR
T1 - Reduction of chromium (vi) and its relationship to carcinogenesis
AU - Shi, Xianglin
AU - Chiu, Arthur
AU - Chen, Chia Ting
AU - Halliwell, Barry
AU - Castranova, Vince
AU - Vallyathan, Val
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) freeradical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'deoxyguanosine, and activation of nuclear transcription factor B.
AB - Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) freeradical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'deoxyguanosine, and activation of nuclear transcription factor B.
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U2 - 10.1080/109374099281241
DO - 10.1080/109374099281241
M3 - Article
C2 - 10081526
AN - SCOPUS:0033374068
SN - 1093-7404
VL - 2
SP - 87
EP - 104
JO - Journal of Toxicology and Environmental Health - Part B: Critical Reviews
JF - Journal of Toxicology and Environmental Health - Part B: Critical Reviews
IS - 1
ER -