The combination of Cp2TiCl2 with 2 equiv of EtMgBr provides an effective reagent for the reductive cyclization of enynes, including ester-containing enynes, to bicyclic titanacyclopentenes. These metallacycles may then be transformed into bicyclic cyclopentenones or iminocyclopentenes in good yields by reaction with CO or an isocyanide, respectively.
|Number of pages||3|
|Journal||Journal of Organic Chemistry|
|State||Published - Oct 1 1992|
ASJC Scopus subject areas
- Organic Chemistry