Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty

George V. Rebec; John R.C. Christensen; Cristiano Guerra; Michael T. Bardo

doi:10.1016/S0006-8993(97)01004-4

Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty

George V. Rebec, John R.C. Christensen, Cristiano Guerra, Michael T. Bardo

Research output: Contribution to journal › Article › peer-review

207 Scopus citations

Abstract

To assess dopamine efflux during novelty-seeking behavior in rats, fast- scan cyclic voltammetry in the nucleus accumbens was combined with free- choice entry into a novel environment. Cyclic voltammograms, confirmed by in vitro testing, revealed that entry into novel, but not familiar, surroundings increased dopamine efflux in a regionally and temporally distinct pattern. Whereas dopamine failed to change in the core region of the accumbens and overlying neostriatum, an abrupt increase occurred in accumbal shell, a limbic-related area implicated in goal-directed behavior. Although the dopamine response was confined to the brief period of entry into novelty (λ 8 s duration), a less rapid and more persistent dopamine change (> 20 s duration) occurred in the shell-core transition zone, the so-called shore. These results suggest that novelty mimics other positively reinforcing stimuli in enhancing dopamine transmission in the nucleus accumbens, but the regional and temporal heterogeneity of this effect may represent different aspects of accumbal dopamine function.

Original language	English
Pages (from-to)	61-67
Number of pages	7
Journal	Brain Research
Volume	776
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(97)01004-4
State	Published - Nov 21 1997

Bibliographical note

Funding Information:
This research was supported by U.S. Public Health Service grants from the National Institute on Drug Abuse (DA 05312 and DA 02451). We also thank P.E. Langley for technical assistance, and F. Caylor for manuscript preparation. Drs. P.A. Garris and R.M. Wightman provided ongoing advice and commentary.

Funding

This research was supported by U.S. Public Health Service grants from the National Institute on Drug Abuse (DA 05312 and DA 02451). We also thank P.E. Langley for technical assistance, and F. Caylor for manuscript preparation. Drs. P.A. Garris and R.M. Wightman provided ongoing advice and commentary.

Funders	Funder number
National Institute on Drug Abuse	DA 02451, P50DA005312
U.S. Public Health Service

Keywords

Core
Dopamine efflux
Fast-scan cyclic voltammetry
Free-choice novelty
Nucleu's accumbens
Shell
Shore

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)01004-4

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title = "Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty",

abstract = "To assess dopamine efflux during novelty-seeking behavior in rats, fast- scan cyclic voltammetry in the nucleus accumbens was combined with free- choice entry into a novel environment. Cyclic voltammograms, confirmed by in vitro testing, revealed that entry into novel, but not familiar, surroundings increased dopamine efflux in a regionally and temporally distinct pattern. Whereas dopamine failed to change in the core region of the accumbens and overlying neostriatum, an abrupt increase occurred in accumbal shell, a limbic-related area implicated in goal-directed behavior. Although the dopamine response was confined to the brief period of entry into novelty (λ 8 s duration), a less rapid and more persistent dopamine change (> 20 s duration) occurred in the shell-core transition zone, the so-called shore. These results suggest that novelty mimics other positively reinforcing stimuli in enhancing dopamine transmission in the nucleus accumbens, but the regional and temporal heterogeneity of this effect may represent different aspects of accumbal dopamine function.",

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note = "Funding Information: This research was supported by U.S. Public Health Service grants from the National Institute on Drug Abuse (DA 05312 and DA 02451). We also thank P.E. Langley for technical assistance, and F. Caylor for manuscript preparation. Drs. P.A. Garris and R.M. Wightman provided ongoing advice and commentary.",

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N2 - To assess dopamine efflux during novelty-seeking behavior in rats, fast- scan cyclic voltammetry in the nucleus accumbens was combined with free- choice entry into a novel environment. Cyclic voltammograms, confirmed by in vitro testing, revealed that entry into novel, but not familiar, surroundings increased dopamine efflux in a regionally and temporally distinct pattern. Whereas dopamine failed to change in the core region of the accumbens and overlying neostriatum, an abrupt increase occurred in accumbal shell, a limbic-related area implicated in goal-directed behavior. Although the dopamine response was confined to the brief period of entry into novelty (λ 8 s duration), a less rapid and more persistent dopamine change (> 20 s duration) occurred in the shell-core transition zone, the so-called shore. These results suggest that novelty mimics other positively reinforcing stimuli in enhancing dopamine transmission in the nucleus accumbens, but the regional and temporal heterogeneity of this effect may represent different aspects of accumbal dopamine function.

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Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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