Regional end-systolic circumferential strain demonstrates compensatory segmental contractile function in patients with ST-segment elevation myocardial infarction

Steve W. Leung, Theresa M. Ratajczak, Mohamed Abo-Aly, Elica Shokri, Ahmed Abdel-Latif, Jonathan F. Wenk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Myocardial strain has shown tremendous promise as a potential diagnostic tool for characterizing ventricular function. With regards to myocardial infarction, global circumferential strain (CS) can be used to assess overall function, while regional CS can identify local alterations in contractility. Currently, there is a lack of data related to regional strain in patients with ST-segment elevation myocardial infarction (STEMI). Thus, the goal of this study was to quantify regional strain patterns in STEMI and normal control patients, measuring both peak CS and end-systolic (ES) CS in the mid-ventricular region. This was done by conducting cardiac magnetic resonance (CMR) imaging acutely after STEMI patients underwent primary percutaneous coronary intervention. The CMR datasets were then analyzed using feature-tracking of the cine images. The patients were broken into three groups: (1) control patients (N = 18), (2) STEMI patients with ejection fraction (EF) ≥ 50% (N = 20), and (3) STEMI patients with EF < 50% (N = 20). The key result of the analysis was that ES CS detected a significant increase in the magnitude of strain in the non-infarcted tissue of STEMI patients with EF ≥ 50% when compared to STEMI patients with EF < 50%, whereas peak CS did not detect any differences. This implies that the tissue in this region is contracting more strongly compared to non-infarcted tissue in STEMI patients with EF < 50%. Thus, regional ES CS could potentially be utilized as a diagnostic tool for assessing STEMI patients, by detecting regional changes in contractility after PCI, which could assist in treatment planning.

Original languageEnglish
Article number110794
JournalJournal of Biomechanics
Volume129
DOIs
StatePublished - Dec 2 2021

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health grants U01 HL133359 (J.W.) and R01 HL124266 (A.A-L.).

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • Cardiac Magnetic Resonance
  • Feature Tracking
  • Left Ventricle

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rehabilitation

Fingerprint

Dive into the research topics of 'Regional end-systolic circumferential strain demonstrates compensatory segmental contractile function in patients with ST-segment elevation myocardial infarction'. Together they form a unique fingerprint.

Cite this