Levels of PLCγ, a phospholipase C (PLC) isozyme, were significantly increased in the cytosol in the injured left cortex (LC) at 5, 30 and 120 min after brain injury. In the same site, although levels of membrane PLC γ did not alter at 5 and 30 min, they were found to be decreased at 2 h after brain injury. In general, the levels of both cytosolic and membrane PLC γ were unaltered in the contralateral right cortex (RC), ipsilateral left hippocampus (LH) and contralateral right hippocampus (RH) between 5 and 120 min after brain injury. These results suggest that, in addition to well- proposed excitatory neurotransmitter-receptor systems, increased levels of P LC γ may also contribute to alterations in PIP2 signal transduction pathway, particularly in the greatest injury site (LC) after lateral EP brain injury.
|Number of pages||4|
|State||Published - Oct 12 1998|
Bibliographical noteFunding Information:
This study was supported by funding from an NIH grant to Dr. M. Renuka Prasad (NS 34264). The authors thank Mrs. Sears and Morgan for the critical reading of the manuscript.
- Brain injury
- Fluid percussion
- Inositol trisphosphate
- Phosphatidylinositol bisphosphate
- Phospholipase Cγ
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology