Regional levels of phospholipase Cγ after fluid percussion brain injury in the rat

Heidi M. Carman, Harbhajan S. Dhillon, Deqing Zhang, James W. Geddes, Renuka M. Prasad

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Levels of PLCγ, a phospholipase C (PLC) isozyme, were significantly increased in the cytosol in the injured left cortex (LC) at 5, 30 and 120 min after brain injury. In the same site, although levels of membrane PLC γ did not alter at 5 and 30 min, they were found to be decreased at 2 h after brain injury. In general, the levels of both cytosolic and membrane PLC γ were unaltered in the contralateral right cortex (RC), ipsilateral left hippocampus (LH) and contralateral right hippocampus (RH) between 5 and 120 min after brain injury. These results suggest that, in addition to well- proposed excitatory neurotransmitter-receptor systems, increased levels of P LC γ may also contribute to alterations in PIP2 signal transduction pathway, particularly in the greatest injury site (LC) after lateral EP brain injury.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalBrain Research
Volume808
Issue number1
DOIs
StatePublished - Oct 12 1998

Bibliographical note

Funding Information:
This study was supported by funding from an NIH grant to Dr. M. Renuka Prasad (NS 34264). The authors thank Mrs. Sears and Morgan for the critical reading of the manuscript.

Keywords

  • Brain injury
  • Diacylglycerol
  • Fluid percussion
  • Inositol trisphosphate
  • Phosphatidylinositol bisphosphate
  • Phospholipase Cγ

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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