Regulation by Ca2+ in the Yersinia low‐Ca2+ response

Susan C. Straley, Gregory V. Plano, Elźbieta Skrzypek, Pryce L. Haddix, Kenneth A. Fields

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations


The Yersinia low‐Ca2+ response (LCR) is a regulatory response in which a set of plasmid‐borne operons is transcriptionally regulated at 37°C in response to the presence or absence of mM concentrations of Ca2+. LCR‐regulated operons encode secreted proteins with regulatory and virulence roles as well as non‐secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane‐bound inductive components. An important rote in LCR induction is played by LcrD, an inner‐membrane protein with homologues in several virulence‐associated and flagella assembly‐related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalMolecular Microbiology
Issue number6
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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