Regulation of ABC transporters at the blood-brain barrier: New targets for CNS therapy

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Worldwide, more than one billion people are affected by CNS disorders. Despite the huge demand for treatments, existing drugs have limited or no efficacy for some neurological diseases, including brain cancer and certain epilepsies. Furthermore, no effective therapies are available at all for some common disorders of the central nervous system (CNS) such as Alzheimer's disease. ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB) have become increasingly important in the treatment and pathogenesis of CNS disorders. Here we highlight a novel strategy - targeting signaling pathways that control ABC transporters at the BBB - to protect the brain, improve brain drug delivery, and reduce CNS pathology.

Original languageEnglish
Pages (from-to)293-304
Number of pages12
JournalMolecular Interventions
Volume10
Issue number5
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Molecular Medicine

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