Regulation of alternative splicing by short non-coding nuclear RNAs

Amit Khanna, Stefan Stamm

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. we review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalRNA Biology
Volume7
Issue number4
DOIs
StatePublished - 2010

Bibliographical note

Funding Information:
This work was supported by EURASNET and the NIH (GM083187 to S.S.).

Keywords

  • Oligonucleotide
  • Prader-Willi syndrome
  • Processed snoRNAs
  • Small nucleolar RNA
  • miRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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