Regulation of alternative splicing by short non-coding nuclear RNAs

Amit Khanna; Stefan Stamm

doi:10.4161/rna.7.4.12746

Regulation of alternative splicing by short non-coding nuclear RNAs

Amit Khanna, Stefan Stamm

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. we review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.

Original language	English
Pages (from-to)	480-485
Number of pages	6
Journal	RNA Biology
Volume	7
Issue number	4
DOIs	https://doi.org/10.4161/rna.7.4.12746
State	Published - 2010

Bibliographical note

Funding Information:
This work was supported by EURASNET and the NIH (GM083187 to S.S.).

Keywords

Oligonucleotide
Prader-Willi syndrome
Processed snoRNAs
Small nucleolar RNA
miRNA

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/rna.7.4.12746

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title = "Regulation of alternative splicing by short non-coding nuclear RNAs",

abstract = "Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. we review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.",

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author = "Amit Khanna and Stefan Stamm",

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AU - Khanna, Amit

AU - Stamm, Stefan

N1 - Funding Information: This work was supported by EURASNET and the NIH (GM083187 to S.S.).

PY - 2010

Y1 - 2010

N2 - Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. we review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.

AB - Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. we review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.

KW - Oligonucleotide

KW - Prader-Willi syndrome

KW - Processed snoRNAs

KW - Small nucleolar RNA

KW - miRNA

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SP - 480

EP - 485

JO - RNA Biology

JF - RNA Biology

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Regulation of alternative splicing by short non-coding nuclear RNAs

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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