Regulation of cancer cell survival by Par-4

Padhma Ranganathan, Vivek M. Rangnekar

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

Original languageEnglish
Pages (from-to)76-85
Number of pages10
JournalAnnals of the New York Academy of Sciences
StatePublished - 2005


  • Apoptosis
  • Cancer
  • Par-4

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science


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