Regulation of cancer cell survival by Par-4

Padhma Ranganathan; Vivek M. Rangnekar

doi:10.1196/annals.1339.046

Regulation of cancer cell survival by Par-4

Padhma Ranganathan, Vivek M. Rangnekar

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

Original language	English
Pages (from-to)	76-85
Number of pages	10
Journal	Annals of the New York Academy of Sciences
Volume	1059
DOIs	https://doi.org/10.1196/annals.1339.046
State	Published - 2005

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R01CA105453
National Childhood Cancer Registry – National Cancer Institute

Keywords

Apoptosis
Cancer
Par-4

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1196/annals.1339.046

Cite this

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title = "Regulation of cancer cell survival by Par-4",

abstract = "Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.",

keywords = "Apoptosis, Cancer, Par-4",

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AU - Rangnekar, Vivek M.

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AB - Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

KW - Apoptosis

KW - Cancer

KW - Par-4

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M3 - Article

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AN - SCOPUS:32244447811

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VL - 1059

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Regulation of cancer cell survival by Par-4

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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