Regulation of cytokine transcription in the context of chromatin

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Understanding the transcriptional regulation of an important class of innate and adaptive immune system effector molecules, the cytokines, is increasingly important given the promise cytokine regulation holds for treating various autoimmune and inflammatory diseases. Studies defining the mechanisms regulating cytokine transcription initially focused on identifying the cis-acting elements and trans-acting factors that activate cytokine promoters and enhancers. In the past, these studies were largely completed in the absence of constraints instituted by cellular chromatin. Over the past decade it has become obvious that changes in chromatin accessibility critically control, rather than simply correlate with, the transcriptional activation of most genes, including cytokines. Hence candidate transcriptional activators are being re-evaluated for potency in the context of cellular chromatin. Several distinct mechanisms for manipulating the generally repressive context of chromatin have been identified for cytokine genes. Most recently, single nucleotide polymorphisms in cytokine transcriptional regulatory elements have been shown to play measurable roles in regulating cytokine levels in the context of naturally selected haplotypes. Overall, subtle differences in DNA sequence and nucleoprotein complex composition, including protein post-translational modification, come together in cell type-specific combinations to explain the normal variation in cytokine transcription throughout the human populace.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number5
StatePublished - Oct 2006

Bibliographical note

Funding Information:
Acknowledgment: Dr. Gerald Denis kindly provided critical review. The author’s work is funded by a Research Grant from the American Diabetes Association.


  • Chromatin remodeling
  • Cytokine transcription
  • Haplotypes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Regulation of cytokine transcription in the context of chromatin'. Together they form a unique fingerprint.

Cite this