Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Csaba Földy, Sang Hun Lee, Robert J. Morgan, Ivan Soltesz

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

Original languageEnglish
Pages (from-to)1047-1049
Number of pages3
JournalNature Neuroscience
Issue number9
StatePublished - Sep 2010

Bibliographical note

Funding Information:
We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).

ASJC Scopus subject areas

  • General Neuroscience


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