Abstract
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
Original language | English |
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Pages (from-to) | 1047-1049 |
Number of pages | 3 |
Journal | Nature Neuroscience |
Volume | 13 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2010 |
Bibliographical note
Funding Information:We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).
ASJC Scopus subject areas
- Neuroscience (all)