Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Csaba Földy; Sang Hun Lee; Robert J. Morgan; Ivan Soltesz

doi:10.1038/nn.2609

Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Csaba Földy, Sang Hun Lee, Robert J. Morgan, Ivan Soltesz

Neuroscience

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABA_A receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

Original language	English
Pages (from-to)	1047-1049
Number of pages	3
Journal	Nature Neuroscience
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/nn.2609
State	Published - Sep 2010

Bibliographical note

Funding Information:
We thank R. Zhu for excellent technical assistance, K. Ding and D. Szabadics for camera lucida reconstructions, M. Case for genotyping, J.E. Melvin for the ClC-2 knockout mouse and L. Hilgenberg, M.A. Smith, M. Cahalan, M.V. Jones, Z. Nusser and R.L. McDonald for discussions. This work was supported by US National Institutes of Health grant NS38580 (to I.S.) and the Epilepsy Foundation through the generous support of the Eric W. Lothman Training Fellowship (to S.-H.L.).

ASJC Scopus subject areas

Neuroscience (all)

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abstract = "Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.",

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Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Abstract

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