Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.
|Number of pages||20|
|Journal||Annual Review of Genetics|
|State||Published - 2019|
Bibliographical noteFunding Information:
We would like to thank Mark M. Miller for the beautiful illustrations he created for Figures 1 and 2. E.M.D. would also like to thank A. Morris and A. Seifert for thoughtful discussions and helpful input. A.S.A. is an investigator of the Howard Hughes Medical Institute and the Stowers Institute for Medical Research. A.S.A. is grateful to the National Institutes of General Medicine for funding part of the research reported here (NIH R37GM057260).
© 2019 Annual Reviews Inc.. All rights reserved.
- stem cell
ASJC Scopus subject areas