TY - JOUR
T1 - Regulation of Genomic Output and (Pluri)potency in Regeneration
AU - Duncan, Elizabeth M.
AU - Sánchez Alvarado, Alejandro
N1 - Publisher Copyright:
© 2019 Annual Reviews Inc.. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.
AB - Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.
KW - chromatin
KW - genomic
KW - methylation
KW - planarian
KW - regeneration
KW - stem cell
UR - http://www.scopus.com/inward/record.url?scp=85076100529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076100529&partnerID=8YFLogxK
U2 - 10.1146/annurev-genet-112618-043733
DO - 10.1146/annurev-genet-112618-043733
M3 - Review article
C2 - 31505134
AN - SCOPUS:85076100529
SN - 0066-4197
VL - 53
SP - 327
EP - 346
JO - Annual Review of Genetics
JF - Annual Review of Genetics
ER -