Regulation of Genomic Output and (Pluri)potency in Regeneration

Elizabeth M. Duncan, Alejandro Sánchez Alvarado

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.

Original languageEnglish
Pages (from-to)327-346
Number of pages20
JournalAnnual Review of Genetics
Volume53
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
We would like to thank Mark M. Miller for the beautiful illustrations he created for Figures 1 and 2. E.M.D. would also like to thank A. Morris and A. Seifert for thoughtful discussions and helpful input. A.S.A. is an investigator of the Howard Hughes Medical Institute and the Stowers Institute for Medical Research. A.S.A. is grateful to the National Institutes of General Medicine for funding part of the research reported here (NIH R37GM057260).

Publisher Copyright:
© 2019 Annual Reviews Inc.. All rights reserved.

Keywords

  • chromatin
  • genomic
  • methylation
  • planarian
  • regeneration
  • stem cell

ASJC Scopus subject areas

  • Genetics

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