Regulation of induced pluripotent stem (iPS) cell induction by Wnt/β-catenin signaling

Peilin Zhang, Wen Hsuan Chang, Brendan Fong, Fan Gao, Chunming Liu, Denise Al Alam, Saverio Bellusci, Wange Lu

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Wnt signaling has been implicated in promoting somatic cell reprogramming. However, its molecular mechanisms remain unknown. Here we report that Wnt/β-catenin enhances iPSCs induction at the early stage of reprogramming. The augmented reprogramming induced by β-catenin is not due to increased total cell population or activation of c-Myc. In addition, β-catenin interacts with reprogramming factors Klf4, Oct4, and Sox2, further enhancing expression of pluripotency circuitry genes. These studies reveal novel mechanisms underlying the regulation of reprogramming somatic cells to pluripotency by Wnt/β-catenin signaling.

Original languageEnglish
Pages (from-to)9221-9232
Number of pages12
JournalJournal of Biological Chemistry
Issue number13
StatePublished - Mar 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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