TY - JOUR
T1 - Regulation of induced pluripotent stem (iPS) cell induction by Wnt/β-catenin signaling
AU - Zhang, Peilin
AU - Chang, Wen Hsuan
AU - Fong, Brendan
AU - Gao, Fan
AU - Liu, Chunming
AU - Alam, Denise Al
AU - Bellusci, Saverio
AU - Lu, Wange
PY - 2014/3/30
Y1 - 2014/3/30
N2 - Wnt signaling has been implicated in promoting somatic cell reprogramming. However, its molecular mechanisms remain unknown. Here we report that Wnt/β-catenin enhances iPSCs induction at the early stage of reprogramming. The augmented reprogramming induced by β-catenin is not due to increased total cell population or activation of c-Myc. In addition, β-catenin interacts with reprogramming factors Klf4, Oct4, and Sox2, further enhancing expression of pluripotency circuitry genes. These studies reveal novel mechanisms underlying the regulation of reprogramming somatic cells to pluripotency by Wnt/β-catenin signaling.
AB - Wnt signaling has been implicated in promoting somatic cell reprogramming. However, its molecular mechanisms remain unknown. Here we report that Wnt/β-catenin enhances iPSCs induction at the early stage of reprogramming. The augmented reprogramming induced by β-catenin is not due to increased total cell population or activation of c-Myc. In addition, β-catenin interacts with reprogramming factors Klf4, Oct4, and Sox2, further enhancing expression of pluripotency circuitry genes. These studies reveal novel mechanisms underlying the regulation of reprogramming somatic cells to pluripotency by Wnt/β-catenin signaling.
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U2 - 10.1074/jbc.M113.542845
DO - 10.1074/jbc.M113.542845
M3 - Article
C2 - 24482235
AN - SCOPUS:84897399472
SN - 0021-9258
VL - 289
SP - 9221
EP - 9232
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 13
ER -