Regulation of ribosome biogenesis in skeletal muscle hypertrophy

Vandré Casagrande Figueiredo, John J. McCarthy

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Here, we provide evidence to support a central role for ribosome biogenesis in skeletal muscle growth during postnatal development and in response to resistance exercise training. Furthermore, we discuss the cellular signaling pathways regulating ribosome biogenesis, discuss how myonuclear accretion affects translational capacity, and explore future areas of investigation within the field.

Original languageEnglish
Pages (from-to)30-42
Number of pages13
JournalPhysiology
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Int. Union Physiol. Sci./Am. Physiol. Soc.

ASJC Scopus subject areas

  • Physiology

Fingerprint

Dive into the research topics of 'Regulation of ribosome biogenesis in skeletal muscle hypertrophy'. Together they form a unique fingerprint.

Cite this