Abstract
The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Here, we provide evidence to support a central role for ribosome biogenesis in skeletal muscle growth during postnatal development and in response to resistance exercise training. Furthermore, we discuss the cellular signaling pathways regulating ribosome biogenesis, discuss how myonuclear accretion affects translational capacity, and explore future areas of investigation within the field.
| Original language | English |
|---|---|
| Pages (from-to) | 30-42 |
| Number of pages | 13 |
| Journal | Physiology |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
Bibliographical note
Publisher Copyright:© 2019 Int. Union Physiol. Sci./Am. Physiol. Soc.
Funding
We thank the anonymous reviewers who have critically evaluated this manuscript. J.J.M. was supported by National Institutes of Health Grants AG-049806 and AR-060701.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | AR-060701 |
| National Institute on Aging | R01AG049806 |
ASJC Scopus subject areas
- Physiology