Regulation of the cholinergic gene locus

Hiromitsu Tanaka, Masahito Shimojo, Donghai Wu, Louis B. Hersh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJournal of Physiology Paris
Volume92
Issue number2
DOIs
StatePublished - Apr 1998

Bibliographical note

Funding Information:
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

Keywords

  • Choline acetyltransferase
  • Coordinate regulation
  • Protein kinase A
  • Transcriptional regulation
  • Vesicular acetylcholine transporter

ASJC Scopus subject areas

  • Neuroscience (all)
  • Physiology (medical)

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