Abstract
DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.
Original language | English |
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Pages (from-to) | 149-152 |
Number of pages | 4 |
Journal | Journal of Physiology Paris |
Volume | 92 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1998 |
Bibliographical note
Funding Information:We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.
Funding
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.
Funders | Funder number |
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National Institutes of Health (NIH) | |
National Institute on Aging | R01AG005893, AG05144 |
Keywords
- Choline acetyltransferase
- Coordinate regulation
- Protein kinase A
- Transcriptional regulation
- Vesicular acetylcholine transporter
ASJC Scopus subject areas
- General Neuroscience
- Physiology (medical)