DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.
|Number of pages||4|
|Journal||Journal of Physiology Paris|
|State||Published - Apr 1998|
Bibliographical noteFunding Information:
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.
- Choline acetyltransferase
- Coordinate regulation
- Protein kinase A
- Transcriptional regulation
- Vesicular acetylcholine transporter
ASJC Scopus subject areas
- Neuroscience (all)
- Physiology (medical)