Regulation of the cholinergic gene locus

Hiromitsu Tanaka, Masahito Shimojo, Donghai Wu, Louis B. Hersh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJournal of Physiology Paris
Issue number2
StatePublished - Apr 1998

Bibliographical note

Funding Information:
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.


  • Choline acetyltransferase
  • Coordinate regulation
  • Protein kinase A
  • Transcriptional regulation
  • Vesicular acetylcholine transporter

ASJC Scopus subject areas

  • Neuroscience (all)
  • Physiology (medical)


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