Regulation of the cholinergic gene locus

Hiromitsu Tanaka; Masahito Shimojo; Donghai Wu; Louis B. Hersh

doi:10.1016/S0928-4257(98)80154-X

Regulation of the cholinergic gene locus

Hiromitsu Tanaka, Masahito Shimojo, Donghai Wu, Louis B. Hersh

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

Original language	English
Pages (from-to)	149-152
Number of pages	4
Journal	Journal of Physiology Paris
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/S0928-4257(98)80154-X
State	Published - Apr 1998

Bibliographical note

Funding Information:
We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

Funding

We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

Funders	Funder number
National Institutes of Health (NIH)
National Institute on Aging	R01AG005893, AG05144

Keywords

Choline acetyltransferase
Coordinate regulation
Protein kinase A
Transcriptional regulation
Vesicular acetylcholine transporter

ASJC Scopus subject areas

General Neuroscience
Physiology (medical)

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10.1016/S0928-4257(98)80154-X

Cite this

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title = "Regulation of the cholinergic gene locus",

abstract = "DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.",

keywords = "Choline acetyltransferase, Coordinate regulation, Protein kinase A, Transcriptional regulation, Vesicular acetylcholine transporter",

author = "Hiromitsu Tanaka and Masahito Shimojo and Donghai Wu and Hersh, \{Louis B.\}",

note = "Funding Information: We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.",

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language = "English",

volume = "92",

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T1 - Regulation of the cholinergic gene locus

AU - Tanaka, Hiromitsu

AU - Shimojo, Masahito

AU - Wu, Donghai

AU - Hersh, Louis B.

N1 - Funding Information: We thank Dr. John Wagner, Cornell University, for providing the PC I2 cell lines used in this study. This work was supported by grants from the NIH, NIA AG05893 and AG05144.

PY - 1998/4

Y1 - 1998/4

N2 - DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

AB - DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.

KW - Choline acetyltransferase

KW - Coordinate regulation

KW - Protein kinase A

KW - Transcriptional regulation

KW - Vesicular acetylcholine transporter

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JO - Journal of Physiology Paris

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IS - 2

ER -

Regulation of the cholinergic gene locus

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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