Rehabilitation and improvement of health-related quality-of-life detriments in individuals with chronic ankle instability: A meta-analysis

Cameron J. Powden, Johanna M. Hoch, Matthew C. Hoch

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective: To conduct a systematic review with metaanalysis assessing the effectiveness of conservative rehabilitation programs for improving health-related quality of life (HRQL) in individuals with chronic ankle instability (CAI). Data Sources: PubMed, MEDLINE, CINAHL, and SPORTDiscus were searched from inception to January 2016. Study Selection: Studies were included if the researchers examined the effects of a conservative rehabilitation protocol in individuals with CAI, used validated patient-reported outcomes (PROs) to quantify participant-perceived HRQL, and provided adequate data to calculate the effect sizes (ESs) and 95% confidence intervals (CIs). Studies were excluded if the authors evaluated surgical interventions, prophylactic taping, or bracing applications or examined only the immediate effects of 1 treatment session. Data Extraction: Two investigators independently assessed methodologic quality using the Physiotherapy Evidence Database (PEDro) Scale. Studies were considered low quality if fewer than 60% of the criteria were met. Level of evidence was assessed using the Strength of Recommendation Taxonomy. Preintervention and postintervention sample sizes, means, and standard deviations of PROs were extracted. Data Synthesis: A total of 15 studies provided 24 participant groups that were included in the analysis. Seven high-quality studies with a median PEDro score of 50% (range = 10%-80%) and a median level of evidence of 2 (range = 1-2) were identified. The magnitudes of preintervention to postintervention PRO differences were examined using bias-corrected Hedges g ESs. Random-effects metaanalysis was performed to synthesize PRO changes across all participant groups. Positive ES values indicated better PRO scores at postintervention than at preintervention. The a level was set at .05. Meta-analysis revealed a strong ES with a nonoverlapping 95% CI (ES = 1.20, CI = 0.80, 1.60; P , .001), indicating HRQL improved after conservative rehabilitation. Conclusions: Based on the quality of the evidence and the results of the meta-analysis, grade A evidence showed that conservative rehabilitation produces large improvements in HRQL for people with CAI.

Original languageEnglish
Pages (from-to)753-765
Number of pages13
JournalJournal of Athletic Training
Issue number8
StatePublished - Aug 2017

Bibliographical note

Publisher Copyright:
© 2017 by the National Athletic Trainers' Association, Inc.


  • Ankle sprains
  • Conservative care
  • Patient-reported outcomes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


Dive into the research topics of 'Rehabilitation and improvement of health-related quality-of-life detriments in individuals with chronic ankle instability: A meta-analysis'. Together they form a unique fingerprint.

Cite this