Reinforcing effects of methylphenidate: Influence of dose and behavioral demands following drug administration

William W. Stoops; Joshua A. Lile; Mark T. Fillmore; Paul E.A. Glaser; Craig R. Rush

doi:10.1007/s00213-004-1946-z

Reinforcing effects of methylphenidate: Influence of dose and behavioral demands following drug administration

William W. Stoops, Joshua A. Lile, Mark T. Fillmore, Paul E.A. Glaser, Craig R. Rush

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Rationale: The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration. Objective: The objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progressive-ratio procedure. Methods: The reinforcing effects of oral methylphenidate (0, 10, 20, and 40 mg) were assessed in seven healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session) and the order of relaxation and performance sessions was constant within a dose condition. Results: Methylphenidate significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Methylphenidate produced comparable stimulant-like subject ratings under both the performance and relaxation conditions. Conclusion: The findings of the present experiment suggest that the reinforcing effects of methylphenidate, like D-amphetamine and cocaine, are influenced by behavioral demands following drug administration.

Original language	English
Pages (from-to)	349-355
Number of pages	7
Journal	Psychopharmacology
Volume	177
Issue number	3
DOIs	https://doi.org/10.1007/s00213-004-1946-z
State	Published - Jan 2005

Bibliographical note

Funding Information:
Acknowledgments This research was supported by Grant DA12665 from the National Institute on Drug Abuse (CRR). The authors wish to thank Frances P. Wagner, RN, Michelle D. Gray, Jamie L. Haga and Allison L. Weber for their expert medical and technical assistance. The present experiment complied with all current laws in the United States of America.

Keywords

Context
Human
Methylphenidate
Performance and relaxation
Progressive-ratio
Reinforcement
Subject-rated effects

ASJC Scopus subject areas

Pharmacology

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10.1007/s00213-004-1946-z

Cite this

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title = "Reinforcing effects of methylphenidate: Influence of dose and behavioral demands following drug administration",

abstract = "Rationale: The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration. Objective: The objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progressive-ratio procedure. Methods: The reinforcing effects of oral methylphenidate (0, 10, 20, and 40 mg) were assessed in seven healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session) and the order of relaxation and performance sessions was constant within a dose condition. Results: Methylphenidate significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Methylphenidate produced comparable stimulant-like subject ratings under both the performance and relaxation conditions. Conclusion: The findings of the present experiment suggest that the reinforcing effects of methylphenidate, like D-amphetamine and cocaine, are influenced by behavioral demands following drug administration.",

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author = "Stoops, {William W.} and Lile, {Joshua A.} and Fillmore, {Mark T.} and Glaser, {Paul E.A.} and Rush, {Craig R.}",

note = "Funding Information: Acknowledgments This research was supported by Grant DA12665 from the National Institute on Drug Abuse (CRR). The authors wish to thank Frances P. Wagner, RN, Michelle D. Gray, Jamie L. Haga and Allison L. Weber for their expert medical and technical assistance. The present experiment complied with all current laws in the United States of America.",

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AU - Stoops, William W.

AU - Lile, Joshua A.

AU - Fillmore, Mark T.

AU - Glaser, Paul E.A.

AU - Rush, Craig R.

N1 - Funding Information: Acknowledgments This research was supported by Grant DA12665 from the National Institute on Drug Abuse (CRR). The authors wish to thank Frances P. Wagner, RN, Michelle D. Gray, Jamie L. Haga and Allison L. Weber for their expert medical and technical assistance. The present experiment complied with all current laws in the United States of America.

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N2 - Rationale: The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration. Objective: The objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progressive-ratio procedure. Methods: The reinforcing effects of oral methylphenidate (0, 10, 20, and 40 mg) were assessed in seven healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session) and the order of relaxation and performance sessions was constant within a dose condition. Results: Methylphenidate significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Methylphenidate produced comparable stimulant-like subject ratings under both the performance and relaxation conditions. Conclusion: The findings of the present experiment suggest that the reinforcing effects of methylphenidate, like D-amphetamine and cocaine, are influenced by behavioral demands following drug administration.

AB - Rationale: The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration. Objective: The objective of this study was to assess the reinforcing effects of methylphenidate under different behavioral demands using a modified progressive-ratio procedure. Methods: The reinforcing effects of oral methylphenidate (0, 10, 20, and 40 mg) were assessed in seven healthy adult volunteers under both performance and relaxation conditions. Performance sessions required volunteers to complete simple arithmetic problems for three 50-min blocks. Relaxation sessions required volunteers to sit quietly in a semi-reclined position in a darkened room for three 50-min blocks. Two sampling sessions (one performance and one relaxation session) always preceded two self-administration sessions (one performance and one relaxation session) and the order of relaxation and performance sessions was constant within a dose condition. Results: Methylphenidate significantly increased break point and number of capsules earned on the modified progressive-ratio procedure as an increasing function of dose under the performance, but not the relaxation, condition. Methylphenidate produced comparable stimulant-like subject ratings under both the performance and relaxation conditions. Conclusion: The findings of the present experiment suggest that the reinforcing effects of methylphenidate, like D-amphetamine and cocaine, are influenced by behavioral demands following drug administration.

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Reinforcing effects of methylphenidate: Influence of dose and behavioral demands following drug administration

Abstract

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Keywords

ASJC Scopus subject areas

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