Relations between mucosal immunity and children's mental health: The role of child sex

Peggy S. Keller; Mona El-Sheikh; Brian Vaughn; Douglas A. Granger

doi:10.1016/j.physbeh.2010.08.012

Relations between mucosal immunity and children's mental health: The role of child sex

Peggy S. Keller
, Mona El-Sheikh
, Brian Vaughn
, Douglas A. Granger

Psychology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

This study examines relations between children's salivary interleukin-6 (IL-6) and secretory immunoglobulin A (SIgA) and mental health. Child sex was considered as a moderator of relations. Data were from 329 normally developing children (M age = 9.85. years; SD = .98. years); 67% of children were European American and 33% were African American. Saliva samples were obtained during the afternoon and assayed for SIgA and IL-6. Parents completed questionnaire measures of child internalizing and externalizing symptoms, and children completed self-report measures of anxiety and depression. Structural equation models were fit to the data, and indicated that greater levels of salivary IL-6 and SIgA were associated with adjustment problems more strongly for girls than for boys.

Original language	English
Pages (from-to)	705-712
Number of pages	8
Journal	Physiology and Behavior
Volume	101
Issue number	5
DOIs	https://doi.org/10.1016/j.physbeh.2010.08.012
State	Published - Dec 2 2010

Funding

Funders	Funder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development	R01HD046795

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Child mental health
Externalizing symptoms
Internalizing symptoms
Mucosal immunity
Salivary interleukin-6
Secretory immunoglobulin A
Sex differences

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Access to Document

10.1016/j.physbeh.2010.08.012

Cite this

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title = "Relations between mucosal immunity and children's mental health: The role of child sex",

abstract = "This study examines relations between children's salivary interleukin-6 (IL-6) and secretory immunoglobulin A (SIgA) and mental health. Child sex was considered as a moderator of relations. Data were from 329 normally developing children (M age = 9.85. years; SD = .98. years); 67\% of children were European American and 33\% were African American. Saliva samples were obtained during the afternoon and assayed for SIgA and IL-6. Parents completed questionnaire measures of child internalizing and externalizing symptoms, and children completed self-report measures of anxiety and depression. Structural equation models were fit to the data, and indicated that greater levels of salivary IL-6 and SIgA were associated with adjustment problems more strongly for girls than for boys.",

keywords = "Child mental health, Externalizing symptoms, Internalizing symptoms, Mucosal immunity, Salivary interleukin-6, Secretory immunoglobulin A, Sex differences",

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doi = "10.1016/j.physbeh.2010.08.012",

language = "English",

volume = "101",

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T1 - Relations between mucosal immunity and children's mental health

T2 - The role of child sex

AU - Keller, Peggy S.

AU - El-Sheikh, Mona

AU - Vaughn, Brian

AU - Granger, Douglas A.

PY - 2010/12/2

Y1 - 2010/12/2

N2 - This study examines relations between children's salivary interleukin-6 (IL-6) and secretory immunoglobulin A (SIgA) and mental health. Child sex was considered as a moderator of relations. Data were from 329 normally developing children (M age = 9.85. years; SD = .98. years); 67% of children were European American and 33% were African American. Saliva samples were obtained during the afternoon and assayed for SIgA and IL-6. Parents completed questionnaire measures of child internalizing and externalizing symptoms, and children completed self-report measures of anxiety and depression. Structural equation models were fit to the data, and indicated that greater levels of salivary IL-6 and SIgA were associated with adjustment problems more strongly for girls than for boys.

AB - This study examines relations between children's salivary interleukin-6 (IL-6) and secretory immunoglobulin A (SIgA) and mental health. Child sex was considered as a moderator of relations. Data were from 329 normally developing children (M age = 9.85. years; SD = .98. years); 67% of children were European American and 33% were African American. Saliva samples were obtained during the afternoon and assayed for SIgA and IL-6. Parents completed questionnaire measures of child internalizing and externalizing symptoms, and children completed self-report measures of anxiety and depression. Structural equation models were fit to the data, and indicated that greater levels of salivary IL-6 and SIgA were associated with adjustment problems more strongly for girls than for boys.

KW - Child mental health

KW - Externalizing symptoms

KW - Internalizing symptoms

KW - Mucosal immunity

KW - Salivary interleukin-6

KW - Secretory immunoglobulin A

KW - Sex differences

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U2 - 10.1016/j.physbeh.2010.08.012

DO - 10.1016/j.physbeh.2010.08.012

M3 - Article

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SN - 0031-9384

VL - 101

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EP - 712

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 5

ER -

Relations between mucosal immunity and children's mental health: The role of child sex

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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