Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures

Dona E.C. Locke; David T.R. Berry; Toufic A. Fakhoury; Frederick A. Schmitt

doi:10.1080/13803390490918183

Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures

Dona E.C. Locke, David T.R. Berry, Toufic A. Fakhoury, Frederick A. Schmitt

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Previous research suggests epilepsy and psychogenic non-epileptic seizure (PNES) patients do not show consistent group differences on neuropsychological measures. However, both groups of patients show decreased neuropsychological performance when compared to a normal population (Cragar, Berry, Fakhoury, Cibula, & Schmitt, 2002). Swanson, Springer, Benbadis, and Morris (2000) have suggested epilepsy patients show decreased neurocognitive functioning due to neuropathology whereas PNES patients show decreased neurocognitive functioning due to psychopathology. Effort has also been implicated as an important factor in neuropsychological test results in general (Green, 2003). The purpose of this study was to investigate the relationships of medical history variables (e.g., duration of disorder), neuropathology, psychopathology, and effort to neuropsychological findings in epilepsy and PNES patients. Neuropsychological functioning was divided into six domains: intelligence, memory, language, executive functions, visual-spatial, and motor. Results indicated that medical history variables were related to intellectual, memory, language, and motor functioning. Psychopathology was associated with all cognitive domains except executive functioning. Effort was related to intellectual, memory, language, visual-spatial, and motor functioning. Neuropathology and diagnosis were related only to memory.

Original language	English
Pages (from-to)	325-340
Number of pages	16
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1080/13803390490918183
State	Published - Apr 2006

Bibliographical note

Funding Information:
Studies contrasting neuropsychological performances of patients with epilepsy and patients with psychogenic nonepileptic seizures (PNES) do not show consistent differences between these groups, although test scores in both patient groups are suggestive of Received 9 April 2004; accepted 29 October 2004. Dona E.C. Locke is now at the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine. This project was supported by the Epilepsy Foundation through the generous support of the American Epilepsy Society. This paper is based on a dissertation submitted by Dona Cragar in partial fulfillment of the requirements for a doctorate in clinical psychology. Thank you to Chantel M. S. Dearth and Chris Miara for their help with data collection, Greg Smith, Ph.D. and Sarah Fischer, M.S., for their statistical advice, and Christi Patten, Ph.D., for her comments on an earlier draft of this manuscript. Address correspondence to Dona E.C. Locke, Department of Psychiatry and Psychology, Mayo Clinic 13400 E. Shea Blvd., Scottsdale, AZ 85259. E-mail: locke.dona@mayo.edu

ASJC Scopus subject areas

Clinical Psychology
Neurology
Clinical Neurology

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10.1080/13803390490918183

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title = "Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures",

abstract = "Previous research suggests epilepsy and psychogenic non-epileptic seizure (PNES) patients do not show consistent group differences on neuropsychological measures. However, both groups of patients show decreased neuropsychological performance when compared to a normal population (Cragar, Berry, Fakhoury, Cibula, & Schmitt, 2002). Swanson, Springer, Benbadis, and Morris (2000) have suggested epilepsy patients show decreased neurocognitive functioning due to neuropathology whereas PNES patients show decreased neurocognitive functioning due to psychopathology. Effort has also been implicated as an important factor in neuropsychological test results in general (Green, 2003). The purpose of this study was to investigate the relationships of medical history variables (e.g., duration of disorder), neuropathology, psychopathology, and effort to neuropsychological findings in epilepsy and PNES patients. Neuropsychological functioning was divided into six domains: intelligence, memory, language, executive functions, visual-spatial, and motor. Results indicated that medical history variables were related to intellectual, memory, language, and motor functioning. Psychopathology was associated with all cognitive domains except executive functioning. Effort was related to intellectual, memory, language, visual-spatial, and motor functioning. Neuropathology and diagnosis were related only to memory.",

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Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures. / Locke, Dona E.C.; Berry, David T.R.; Fakhoury, Toufic A. et al.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 28, No. 3, 04.2006, p. 325-340.

Research output: Contribution to journal › Article › peer-review

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Relationship of indicators of neuropathology, psychopathology, and effort to neuropsychological results in patients with epilepsy or psychogenic non-epileptic seizures

Abstract

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ASJC Scopus subject areas

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