Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

K. J. Joshipura; M. O. Andriankaja; F. B. Hu; C. S. Ritchie

doi:10.1016/j.diabres.2011.05.035

Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

K. J. Joshipura, M. O. Andriankaja, F. B. Hu, C. S. Ritchie

Diabetes & Obesity Research Priority Area

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background and aims: Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results: Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions: The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.

Original language	English
Pages (from-to)	268-275
Number of pages	8
Journal	Diabetes Research and Clinical Practice
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/j.diabres.2011.05.035
State	Published - Aug 2011

Bibliographical note

Funding Information:
The authors would like to acknowledge the SOALS team (Dr. Enrique Santiago, Dr. Mauricio Montero, Dr. Pedro Hernandez, Dr. Cynthia Pérez, Ms. Sasha Martínez, Mr. José L. Vergara, Mr. Francisco Muñoz, Mr. Gustavo Sanchez, Mr. Kristian Poventud, Ms. Jennifer Colon, Ms. Nilda González, Dr. Cristina Palacios, Dr. Juan Carlos Zevallos, Mr. Reinaldo Deliz, Ms. Jhezanuel Goncalves, Ms. Lumarie Cuadrado, Dr. Maribel Campos and Dr. Alberto Carrera for their help with the study. This investigation was supported by National Institutes of Health grants K24DE16884 . Grant Number G12RR03051(RCMI Program UPR Medical Sciences Campus), from the NCRR and the Clinical Research Center.

Funding

The authors would like to acknowledge the SOALS team (Dr. Enrique Santiago, Dr. Mauricio Montero, Dr. Pedro Hernandez, Dr. Cynthia Pérez, Ms. Sasha Martínez, Mr. José L. Vergara, Mr. Francisco Muñoz, Mr. Gustavo Sanchez, Mr. Kristian Poventud, Ms. Jennifer Colon, Ms. Nilda González, Dr. Cristina Palacios, Dr. Juan Carlos Zevallos, Mr. Reinaldo Deliz, Ms. Jhezanuel Goncalves, Ms. Lumarie Cuadrado, Dr. Maribel Campos and Dr. Alberto Carrera for their help with the study. This investigation was supported by National Institutes of Health grants K24DE16884 . Grant Number G12RR03051(RCMI Program UPR Medical Sciences Campus), from the NCRR and the Clinical Research Center.

Funders	Funder number
National Institutes of Health (NIH)	G12RR03051
National Institute of Dental and Craniofacial Research	K24DE016884
National Center for Research Resources

Keywords

1-h OGTT
2-h OGTT
Abnormal glucose homeostasis
Glucose abnormalities
Type 2 diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2011.05.035

Cite this

@article{650b51ade049432fb8203503858abca3,

title = "Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis",

abstract = "Background and aims: Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results: Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions: The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.",

keywords = "1-h OGTT, 2-h OGTT, Abnormal glucose homeostasis, Glucose abnormalities, Type 2 diabetes",

author = "Joshipura, {K. J.} and Andriankaja, {M. O.} and Hu, {F. B.} and Ritchie, {C. S.}",

note = "Funding Information: The authors would like to acknowledge the SOALS team (Dr. Enrique Santiago, Dr. Mauricio Montero, Dr. Pedro Hernandez, Dr. Cynthia P{\'e}rez, Ms. Sasha Mart{\'i}nez, Mr. Jos{\'e} L. Vergara, Mr. Francisco Mu{\~n}oz, Mr. Gustavo Sanchez, Mr. Kristian Poventud, Ms. Jennifer Colon, Ms. Nilda Gonz{\'a}lez, Dr. Cristina Palacios, Dr. Juan Carlos Zevallos, Mr. Reinaldo Deliz, Ms. Jhezanuel Goncalves, Ms. Lumarie Cuadrado, Dr. Maribel Campos and Dr. Alberto Carrera for their help with the study. This investigation was supported by National Institutes of Health grants K24DE16884 . Grant Number G12RR03051(RCMI Program UPR Medical Sciences Campus), from the NCRR and the Clinical Research Center. ",

year = "2011",

month = aug,

doi = "10.1016/j.diabres.2011.05.035",

language = "English",

volume = "93",

pages = "268--275",

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T1 - Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

AU - Joshipura, K. J.

AU - Andriankaja, M. O.

AU - Hu, F. B.

AU - Ritchie, C. S.

N1 - Funding Information: The authors would like to acknowledge the SOALS team (Dr. Enrique Santiago, Dr. Mauricio Montero, Dr. Pedro Hernandez, Dr. Cynthia Pérez, Ms. Sasha Martínez, Mr. José L. Vergara, Mr. Francisco Muñoz, Mr. Gustavo Sanchez, Mr. Kristian Poventud, Ms. Jennifer Colon, Ms. Nilda González, Dr. Cristina Palacios, Dr. Juan Carlos Zevallos, Mr. Reinaldo Deliz, Ms. Jhezanuel Goncalves, Ms. Lumarie Cuadrado, Dr. Maribel Campos and Dr. Alberto Carrera for their help with the study. This investigation was supported by National Institutes of Health grants K24DE16884 . Grant Number G12RR03051(RCMI Program UPR Medical Sciences Campus), from the NCRR and the Clinical Research Center.

PY - 2011/8

Y1 - 2011/8

N2 - Background and aims: Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results: Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions: The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.

AB - Background and aims: Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results: Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions: The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.

KW - 1-h OGTT

KW - 2-h OGTT

KW - Abnormal glucose homeostasis

KW - Glucose abnormalities

KW - Type 2 diabetes

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Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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