Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

K. J. Joshipura, M. O. Andriankaja, F. B. Hu, C. S. Ritchie

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background and aims: Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results: Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions: The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume93
Issue number2
DOIs
StatePublished - Aug 2011

Bibliographical note

Funding Information:
The authors would like to acknowledge the SOALS team (Dr. Enrique Santiago, Dr. Mauricio Montero, Dr. Pedro Hernandez, Dr. Cynthia Pérez, Ms. Sasha Martínez, Mr. José L. Vergara, Mr. Francisco Muñoz, Mr. Gustavo Sanchez, Mr. Kristian Poventud, Ms. Jennifer Colon, Ms. Nilda González, Dr. Cristina Palacios, Dr. Juan Carlos Zevallos, Mr. Reinaldo Deliz, Ms. Jhezanuel Goncalves, Ms. Lumarie Cuadrado, Dr. Maribel Campos and Dr. Alberto Carrera for their help with the study. This investigation was supported by National Institutes of Health grants K24DE16884 . Grant Number G12RR03051(RCMI Program UPR Medical Sciences Campus), from the NCRR and the Clinical Research Center.

Keywords

  • 1-h OGTT
  • 2-h OGTT
  • Abnormal glucose homeostasis
  • Glucose abnormalities
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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