Abstract
Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E−/− mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/− mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.
| Original language | English |
|---|---|
| Pages (from-to) | 888-890 |
| Number of pages | 3 |
| Journal | Circulation Journal |
| Volume | 81 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2017 |
Bibliographical note
Publisher Copyright:© 2017, Japanese Circulation Society. All rights reserved.
Funding
We thank Mr. Mark Bostrom for his technical assistance with the MMP-9 genetic mouse studies and Dr. Richard Charnigo in the Department of Statistics, University of Kentucky for helping with the statistical analyses. Relaxin study was supported by an award from Merck & Co., Inc. Mmp9−/− mouse study was supported by the National Institutes of Health under award numbers R01 HL107319 and HL133723. The content of this report is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | HL133723, R01 HL107319 |
| Merck |
Keywords
- Abdominal aortic aneurysm
- Matrix metalloproteinase
- Relaxin
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine