RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells

Aaron K. Holley, Yong Xu, Daret K.St Clair, William H.St Clair

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Radiation therapy is in the front line for treatment of localized prostate cancer. However, a significant percentage of patients have radiation-resistant disease. The NF-κB pathway is an important factor for radiation resistance, and the classical (canonical) pathway is thought to confer protection of prostate cancer cells from ionizing radiation. Recently, the alternative (non-canonical) pathway, which is involved in prostate cancer aggressiveness, has also been shown to be important for radiation resistance in prostate cancer. The alternative NF-κB pathway component RelB protects prostate cancer cells from the detrimental effects of ionizing radiation, in part, by stimulating expression of the mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD). Blocking RelB activation suppresses MnSOD expression and sensitizes prostate cancer cells to radiation. These results suggest that RelB-mediated modulation of the antioxidant capacity of prostate cancer cells is an important mechanism of radiation resistance. Therefore, targeting RelB activation may prove to be a valuable weapon in the oncologist's arsenal to defeat aggressive and radiation-resistant prostate cancer.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1201
DOIs
StatePublished - Jul 2010

Keywords

  • RelB
  • manganese superoxide dismutase
  • prostate cancer
  • radiation resistance

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science

Fingerprint

Dive into the research topics of 'RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells'. Together they form a unique fingerprint.

Cite this