Reliability of gait in multiple sclerosis over 6 months

Jacob J. Sosnoff; Rachel E. Klaren; Lara A. Pilutti; Deirdre Dlugonski; Robert W. Motl

doi:10.1016/j.gaitpost.2015.02.006

Reliability of gait in multiple sclerosis over 6 months

Jacob J. Sosnoff, Rachel E. Klaren, Lara A. Pilutti, Deirdre Dlugonski, Robert W. Motl

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Gait impairment is ubiquitous in multiple sclerosis (MS) and is often characterized by alterations in spatiotemporal parameters of gait. There is limited information concerning reliability of spatiotemporal gait parameters over clinical timescales (e.g. 6 months). The current report provides novel evidence that gait parameters of 74 ambulatory persons with MS with mild-to-moderate disability are reliable over 6-months (ICC's for overall sample range from 0.56 to 0.91) in the absence of any intervention above and beyond standard care. Such data can inform clinical decision-making and power analyses for designing RCTs (i.e., sample size estimates) involving persons with MS.

Original language	English
Pages (from-to)	860-862
Number of pages	3
Journal	Gait and Posture
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/j.gaitpost.2015.02.006
State	Published - Mar 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Funding

This project was funded in part by the National Multiple Sclerosis Society ( PP 1695 ).

Funders	Funder number
National Multiple Sclerosis Society	PP 1695

Keywords

Gait
Locomotion
Multiple sclerosis
Reliability
Sample size estimates

ASJC Scopus subject areas

Biophysics
Orthopedics and Sports Medicine
Rehabilitation

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10.1016/j.gaitpost.2015.02.006

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title = "Reliability of gait in multiple sclerosis over 6 months",

abstract = "Gait impairment is ubiquitous in multiple sclerosis (MS) and is often characterized by alterations in spatiotemporal parameters of gait. There is limited information concerning reliability of spatiotemporal gait parameters over clinical timescales (e.g. 6 months). The current report provides novel evidence that gait parameters of 74 ambulatory persons with MS with mild-to-moderate disability are reliable over 6-months (ICC's for overall sample range from 0.56 to 0.91) in the absence of any intervention above and beyond standard care. Such data can inform clinical decision-making and power analyses for designing RCTs (i.e., sample size estimates) involving persons with MS.",

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AU - Sosnoff, Jacob J.

AU - Klaren, Rachel E.

AU - Pilutti, Lara A.

AU - Dlugonski, Deirdre

AU - Motl, Robert W.

PY - 2015/3/1

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AB - Gait impairment is ubiquitous in multiple sclerosis (MS) and is often characterized by alterations in spatiotemporal parameters of gait. There is limited information concerning reliability of spatiotemporal gait parameters over clinical timescales (e.g. 6 months). The current report provides novel evidence that gait parameters of 74 ambulatory persons with MS with mild-to-moderate disability are reliable over 6-months (ICC's for overall sample range from 0.56 to 0.91) in the absence of any intervention above and beyond standard care. Such data can inform clinical decision-making and power analyses for designing RCTs (i.e., sample size estimates) involving persons with MS.

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KW - Locomotion

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KW - Reliability

KW - Sample size estimates

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Reliability of gait in multiple sclerosis over 6 months

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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