Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Douglas H. Smith; Brian R. Perri; Ramesh Raghupathi; Kathryn E. Saatman; Tracy K. McIntosh

doi:10.1016/S0304-3940(97)00551-X

Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Douglas H. Smith, Brian R. Perri, Ramesh Raghupathi, Kathryn E. Saatman, Tracy K. McIntosh

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	Neuroscience Letters
Volume	231
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(97)00551-X
State	Published - Aug 15 1997

Bibliographical note

Funding Information:
We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.

Keywords

2,3,5-Triphenyltetrazolium chloride
Brain trauma
Lesion volume
Memory
Neuroprotection
Remacemide hydrochloride

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/S0304-3940(97)00551-X

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abstract = "We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.",

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note = "Funding Information: We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818. ",

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AU - Saatman, Kathryn E.

AU - McIntosh, Tracy K.

N1 - Funding Information: We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.

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N2 - We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.

AB - We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.

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KW - Memory

KW - Neuroprotection

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Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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