Abstract
We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.
Original language | English |
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Pages (from-to) | 135-138 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 231 |
Issue number | 3 |
DOIs | |
State | Published - Aug 15 1997 |
Bibliographical note
Funding Information:We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.
Funding
We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.
Funders | Funder number |
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Astra Charnwood, Loughborough Leics. | |
National Institutes of Health (NIH) | AG12527, NS08803 |
National Institute of Neurological Disorders and Stroke | R01NS026818 |
Keywords
- 2,3,5-Triphenyltetrazolium chloride
- Brain trauma
- Lesion volume
- Memory
- Neuroprotection
- Remacemide hydrochloride
ASJC Scopus subject areas
- General Neuroscience