We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.
|Number of pages||4|
|State||Published - Aug 15 1997|
Bibliographical noteFunding Information:
We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.
- 2,3,5-Triphenyltetrazolium chloride
- Brain trauma
- Lesion volume
- Remacemide hydrochloride
ASJC Scopus subject areas
- Neuroscience (all)