Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Douglas H. Smith, Brian R. Perri, Ramesh Raghupathi, Kathryn E. Saatman, Tracy K. McIntosh

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Aug 15 1997

Bibliographical note

Funding Information:
We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.


  • 2,3,5-Triphenyltetrazolium chloride
  • Brain trauma
  • Lesion volume
  • Memory
  • Neuroprotection
  • Remacemide hydrochloride

ASJC Scopus subject areas

  • General Neuroscience


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