Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Douglas H. Smith, Brian R. Perri, Ramesh Raghupathi, Kathryn E. Saatman, Tracy K. McIntosh

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We evaluated the therapeutic effects of remacemide hydrochloride, an N- methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalNeuroscience Letters
Volume231
Issue number3
DOIs
StatePublished - Aug 15 1997

Bibliographical note

Funding Information:
We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.

Funding

We would like to thank Jeanne Marks for her excellent preparation of this manuscript. This work was supported, in part, by a grant from Astra Charnwood, Loughborough Leics., UK and from NIH grants AG12527, NS08803, and NS26818.

FundersFunder number
Astra Charnwood, Loughborough Leics.
National Institutes of Health (NIH)AG12527, NS08803
National Institute of Neurological Disorders and StrokeR01NS026818

    Keywords

    • 2,3,5-Triphenyltetrazolium chloride
    • Brain trauma
    • Lesion volume
    • Memory
    • Neuroprotection
    • Remacemide hydrochloride

    ASJC Scopus subject areas

    • General Neuroscience

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