Renal nerves and the development of Dahl salt-sensitive hypertension

J. L. Osborn, R. J. Roman, J. D. Ewens

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34 Scopus citations

Abstract

Several experimental forms of hypertension require intact renal innervation for the development or maintenance (or both) of the elevated arterial pressure. We determined the relationships between urinary sodium and water excretion and arterial pressure in Dahl salt-sensitive rats (DS) with innervated (n = 6) and denervated (n = 7) kidneys after switching from a low to a high sodium diet. Arterial pressure significantly increased in both groups within 48 hours after they began to eat an 8% sodium chloride diet. This hypertension increased to 188 ± 9 and 190 ± 7 mm Hg, respectively, in rats with innervated and denervated kidneys after 12 days. Mean arterial pressures were not significantly different between groups on any day. The rise in arterial pressure of DS placed on a high sodium intake was associated with an elevation of urine flow rate and urinary sodium excretion in rats with either innervated or denervated kidneys. Urine flow rates and urinary sodium excretions were greater in denervated than in innervated rats on Days 4 through 7 after beginning the high sodium diet. This diuresis and natriuresis in rats with denervated kidneys were associated with greater water and sodium intake on Days 4 to 7 of the high sodium diet when compared with rats with innervated kidneys. These results demonstrate that, following exposure to a high sodium intake, DS have increased arterial pressure within 24 hours. The development of this arterial hypertension is not dependent on intact renal innervation. In conscious DS, the renal innervation does participate in the regulation of urinary sodium excretion by promoting renal sodium and water reabsorption. However, DS with either innervated or denervated kidneys maintained sodium balance and rapidly became hypertensive when fed a high salt diet. Thus, elevation of sodium intake in DS results in arterial hypertension independent of measurable renal neurogenic alterations in salt and water balance.

Original languageEnglish
Pages (from-to)523-528
Number of pages6
JournalHypertension
Volume11
Issue number6 PART 1
DOIs
StatePublished - 1988

Funding

FundersFunder number
National Heart, Lung, and Blood Institute (NHLBI)R37HL036279

    ASJC Scopus subject areas

    • Internal Medicine

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