TY - JOUR
T1 - Renal Osteodystrophy
AU - Malluche, Harmut H.
AU - Faugere, Marie Claude
PY - 1989/8/3
Y1 - 1989/8/3
N2 - Replacement of the kidney's excretory function by dialysis has prolonged life, but it has also revealed the extent and importance of the organ's endocrine function. Lacking the kidney's endocrine contributions, patients undergoing long-term maintenance dialysis have considerable morbidity and mortality. Renal osteodystrophy, which is related to the diminished production of 1,25-dihydroxyvitamin D (1,25D), is one abnormality that results from the disturbed endocrine function of failing kidneys. Current research is attempting to unravel the pathogenetic events and underlying mechanisms of uremic osteodystrophy. These include, in addition to the increased excretion of phosphate per nephron and the impaired production of 1,25D, the….
AB - Replacement of the kidney's excretory function by dialysis has prolonged life, but it has also revealed the extent and importance of the organ's endocrine function. Lacking the kidney's endocrine contributions, patients undergoing long-term maintenance dialysis have considerable morbidity and mortality. Renal osteodystrophy, which is related to the diminished production of 1,25-dihydroxyvitamin D (1,25D), is one abnormality that results from the disturbed endocrine function of failing kidneys. Current research is attempting to unravel the pathogenetic events and underlying mechanisms of uremic osteodystrophy. These include, in addition to the increased excretion of phosphate per nephron and the impaired production of 1,25D, the….
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U2 - 10.1056/NEJM198908033210509
DO - 10.1056/NEJM198908033210509
M3 - Editorial
C2 - 2747771
AN - SCOPUS:0024407422
SN - 0028-4793
VL - 321
SP - 317
EP - 319
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 5
ER -