Renewal of sucrose-seeking behavior in rats: Role of D2 dopamine receptors

Anthony S. Rauhut; Laura Fenton; Michael T. Bardo

doi:10.1016/j.pbb.2010.06.006

Renewal of sucrose-seeking behavior in rats: Role of D₂ dopamine receptors

Anthony S. Rauhut, Laura Fenton, Michael T. Bardo

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D₂) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D₂ dopamine receptor antagonist eticlopride (5, 10, 20, or 40μg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40μg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D₂ dopamine receptors in mediating renewal of sucrose-seeking behavior.

Original language	English
Pages (from-to)	354-362
Number of pages	9
Journal	Pharmacology Biochemistry and Behavior
Volume	96
Issue number	3
DOIs	https://doi.org/10.1016/j.pbb.2010.06.006
State	Published - Sep 2010

Bibliographical note

Funding Information:
This study was supported by a grant ( USPHS DA07746 ) awarded to Michael T. Bardo. Anthony S. Rauhut was supported by an NIH, training grant ( USPHS DA07304 ) from NIDA and a Petite-Grant Award from the University of Kentucky . Anthony S. Rauhut also was supported by a grant ( USPHS DA019866 ) in the preparation of this manuscript. Laura A. Fenton was supported by a Kentucky Young Researchers Grant .

Funding

This study was supported by a grant ( USPHS DA07746 ) awarded to Michael T. Bardo. Anthony S. Rauhut was supported by an NIH, training grant ( USPHS DA07304 ) from NIDA and a Petite-Grant Award from the University of Kentucky . Anthony S. Rauhut also was supported by a grant ( USPHS DA019866 ) in the preparation of this manuscript. Laura A. Fenton was supported by a Kentucky Young Researchers Grant .

Funders	Funder number
Kentucky Young Researchers Program
National Institutes of Health (NIH)
National Institute on Drug Abuse	R37DA007304
University of Kentucky	USPHS DA019866

Keywords

Dopamine
Eticlopride
Extinction
Operant
Renewal
Sucrose

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/j.pbb.2010.06.006

Cite this

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title = "Renewal of sucrose-seeking behavior in rats: Role of D2 dopamine receptors",

abstract = "The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D2) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D2 dopamine receptor antagonist eticlopride (5, 10, 20, or 40μg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40μg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D2 dopamine receptors in mediating renewal of sucrose-seeking behavior.",

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