Abstract
The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D2) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D2 dopamine receptor antagonist eticlopride (5, 10, 20, or 40μg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40μg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D2 dopamine receptors in mediating renewal of sucrose-seeking behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 354-362 |
| Number of pages | 9 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 96 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2010 |
Bibliographical note
Funding Information:This study was supported by a grant ( USPHS DA07746 ) awarded to Michael T. Bardo. Anthony S. Rauhut was supported by an NIH, training grant ( USPHS DA07304 ) from NIDA and a Petite-Grant Award from the University of Kentucky . Anthony S. Rauhut also was supported by a grant ( USPHS DA019866 ) in the preparation of this manuscript. Laura A. Fenton was supported by a Kentucky Young Researchers Grant .
Keywords
- Dopamine
- Eticlopride
- Extinction
- Operant
- Renewal
- Sucrose
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience