Renewal of sucrose-seeking behavior in rats: Role of D2 dopamine receptors

Anthony S. Rauhut, Laura Fenton, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D2) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D2 dopamine receptor antagonist eticlopride (5, 10, 20, or 40μg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40μg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D2 dopamine receptors in mediating renewal of sucrose-seeking behavior.

Original languageEnglish
Pages (from-to)354-362
Number of pages9
JournalPharmacology Biochemistry and Behavior
Issue number3
StatePublished - Sep 2010

Bibliographical note

Funding Information:
This study was supported by a grant ( USPHS DA07746 ) awarded to Michael T. Bardo. Anthony S. Rauhut was supported by an NIH, training grant ( USPHS DA07304 ) from NIDA and a Petite-Grant Award from the University of Kentucky . Anthony S. Rauhut also was supported by a grant ( USPHS DA019866 ) in the preparation of this manuscript. Laura A. Fenton was supported by a Kentucky Young Researchers Grant .


  • Dopamine
  • Eticlopride
  • Extinction
  • Operant
  • Renewal
  • Sucrose

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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