Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Emily D. Klein; Brenda J. Gehrke; Thomas A. Green; Thomas R. Zentall; Michael T. Bardo

doi:10.1016/j.lmot.2006.07.004

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Emily D. Klein
, Brenda J. Gehrke
, Thomas A. Green
, Thomas R. Zentall
, Michael T. Bardo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

Original language	English
Pages (from-to)	44-55
Number of pages	12
Journal	Learning and Motivation
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.lmot.2006.07.004
State	Published - Feb 2007

Bibliographical note

Funding Information:
This research was supported by USPHS grant DA12964 awarded to Michael Bardo and grant DA18476 awarded to Emily Klein.

Funding

This research was supported by USPHS grant DA12964 awarded to Michael Bardo and grant DA18476 awarded to Emily Klein.

Funders	Funder number
U.S. Public Health Service	DA18476, DA12964

Keywords

Cocaine
Environmental enrichment
Fixed ratio
Locomotor
Sensitization
Sucrose

ASJC Scopus subject areas

Health(social science)
Neuropsychology and Physiological Psychology
Experimental and Cognitive Psychology
Education
Developmental and Educational Psychology

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10.1016/j.lmot.2006.07.004

Cite this

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title = "Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats",

abstract = "The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.",

keywords = "Cocaine, Environmental enrichment, Fixed ratio, Locomotor, Sensitization, Sucrose",

author = "Klein, \{Emily D.\} and Gehrke, \{Brenda J.\} and Green, \{Thomas A.\} and Zentall, \{Thomas R.\} and Bardo, \{Michael T.\}",

note = "Funding Information: This research was supported by USPHS grant DA12964 awarded to Michael Bardo and grant DA18476 awarded to Emily Klein. ",

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AU - Klein, Emily D.

AU - Gehrke, Brenda J.

AU - Green, Thomas A.

AU - Zentall, Thomas R.

AU - Bardo, Michael T.

N1 - Funding Information: This research was supported by USPHS grant DA12964 awarded to Michael Bardo and grant DA18476 awarded to Emily Klein.

PY - 2007/2

Y1 - 2007/2

N2 - The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

AB - The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

KW - Cocaine

KW - Environmental enrichment

KW - Fixed ratio

KW - Locomotor

KW - Sensitization

KW - Sucrose

UR - https://www.scopus.com/pages/publications/33846850138

UR - https://www.scopus.com/pages/publications/33846850138#tab=citedBy

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DO - 10.1016/j.lmot.2006.07.004

M3 - Article

AN - SCOPUS:33846850138

SN - 0023-9690

VL - 38

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JO - Learning and Motivation

JF - Learning and Motivation

IS - 1

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Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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