Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Lucas S. Broster, Juan Li, Charles D. Smith, Gregory A. Jicha, Frederick A. Schmitt, Yang Jiang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

Original languageEnglish
Pages (from-to)946-959
Number of pages14
JournalJournal of Clinical and Experimental Neuropsychology
Volume35
Issue number9
DOIs
StatePublished - Nov 1 2013

Bibliographical note

Funding Information:
This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

Keywords

  • Aging
  • Alzheimer disease
  • Cognitive therapy
  • Mild cognitive impairment
  • Neuropsychological tests
  • Repetition priming
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Psychology

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