Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Lucas S. Broster; Juan Li; Charles D. Smith; Gregory A. Jicha; Frederick A. Schmitt; Yang Jiang

doi:10.1080/13803395.2013.838942

Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Lucas S. Broster, Juan Li, Charles D. Smith, Gregory A. Jicha, Frederick A. Schmitt, Yang Jiang

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

Original language	English
Pages (from-to)	946-959
Number of pages	14
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	35
Issue number	9
DOIs	https://doi.org/10.1080/13803395.2013.838942
State	Published - Nov 1 2013

Bibliographical note

Funding Information:
This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

Keywords

Aging
Alzheimer disease
Cognitive therapy
Mild cognitive impairment
Neuropsychological tests
Repetition priming
Working memory

ASJC Scopus subject areas

Clinical Psychology
Neurology
Clinical Neurology

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10.1080/13803395.2013.838942

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title = "Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment",

abstract = "Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.",

keywords = "Aging, Alzheimer disease, Cognitive therapy, Mild cognitive impairment, Neuropsychological tests, Repetition priming, Working memory",

author = "Broster, {Lucas S.} and Juan Li and Smith, {Charles D.} and Jicha, {Gregory A.} and Schmitt, {Frederick A.} and Yang Jiang",

note = "Funding Information: This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.",

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AU - Li, Juan

AU - Smith, Charles D.

AU - Jicha, Gregory A.

AU - Schmitt, Frederick A.

AU - Jiang, Yang

N1 - Funding Information: This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.

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N2 - Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.

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Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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