Repeated subcutaneous administration of PT150 has dose-dependent effects on sign tracking in male Japanese quail

Beth Ann Rice, Meredith A. Saunders, Julia E. Jagielo-Miller, Mark A. Prendergast, Chana K. Akins

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A devastating feature of drug dependence is the susceptibility of relapse (40-60%) after stretches of abstinence. In both animal and human research, it has been demonstrated that cues (e.g., levers, paraphernalia) associated with drug reward can instigate renewed drug taking. Research has shown animals that attend to a cue that predicts reward more than the location of reward delivery when the cue is present (sign trackers) have an increase in corticosterone (CORT), a primary stress hormone when compared with animals that do not sign track. This interaction of sign tracking and CORT implicate CORT's effects as a possible pharmacological target for cue-induced relapse behaviors. PT150 is a novel glucocorticoid receptor antagonist that reduces the effects of CORT. Previous research has shown that oral administration of 40 mg/kg PT150 reduced sign tracking. To better understand dose-dependent effects and to control for more accurate doses, the current experiment hypothesized that PT150 (20/40/60 mg/kg) given by subcutaneous (SC) injection to male quail would reduce sign tracking to a keylight conditional stimulus that predicts a grain unconditioned stimulus dose dependently. Results showed that SC injection of 20 mg/kg PT150 reduced sign tracking, but 40 or 60 mg/kg did not. The main findings from the current study are that the glucocorticoid receptor antagonist PT150 reduces sign tracking behavior dose dependently, and SC administration may provide better bioavailability compared with our previous study that used an oral route of administration. The current findings support previous literature by suggesting that the glucocorticoid receptor may be a potential pharmacological target for reducing relapse-like behaviors.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalExperimental and Clinical Psychopharmacology
Volume27
Issue number6
DOIs
StatePublished - Dec 2019

Bibliographical note

Funding Information:
This research was supported by Lyman T. Johnson Academic Year Fellowship(s) (awarded to Beth Ann Rice), and the National Institute on Drug Abuse of the National Institutes of Healh (grant T32DA03520 awarded to Rush which supported the training grant for Beth Ann Rice; grant R01DA025032 awarded to Chana K. Akins).

Publisher Copyright:
© 2019 American Psychological Association.

Keywords

  • Addiction
  • Corticosterone
  • Glucocorticoids
  • Quail
  • Sign tracking

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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