TY - JOUR
T1 - Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites
AU - Shrestha, Sadeep
AU - Yan, Qi
AU - Joseph, Gregory
AU - Arnett, Donna K.
AU - Martinson, Jeremy J.
AU - Kingsley, Lawrence A.
PY - 2012/7/31
Y1 - 2012/7/31
N2 - To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
AB - To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
UR - http://www.scopus.com/inward/record.url?scp=84864278458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864278458&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e328355359f
DO - 10.1097/QAD.0b013e328355359f
M3 - Article
C2 - 22627881
AN - SCOPUS:84864278458
SN - 0269-9370
VL - 26
SP - 1571
EP - 1573
JO - AIDS
JF - AIDS
IS - 12
ER -
