Replicon particle vaccine protects swine against influenza

B. Bosworth; M. M. Erdman; D. L. Stine; I. Harris; C. Irwin; M. Jens; A. Loynachan; K. Kamrud; D. L. Harris

doi:10.1016/j.cimid.2010.05.002

Replicon particle vaccine protects swine against influenza

B. Bosworth, M. M. Erdman, D. L. Stine, I. Harris, C. Irwin, M. Jens, A. Loynachan, K. Kamrud, D. L. Harris

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.

Original language	English
Pages (from-to)	e99-e103
Journal	Comparative Immunology, Microbiology and Infectious Diseases
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.cimid.2010.05.002
State	Published - Dec 2010

Bibliographical note

Funding Information:
The project was funded by the Grow Iowa Value Fund and Iowa Pork Board. Appreciation is expressed to Abbie Loynachan, Mark Mogler, Ryan Vander Veen, Andrea Holcombe and Steve Gaul for assistance.

Keywords

Hemagglutinin (HA)
Maternal antibody
Pigs
Replicon particle (RP) vaccine
Swine
Swine influenza virus (SIV)

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Immunology
General Veterinary
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cimid.2010.05.002

Cite this

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title = "Replicon particle vaccine protects swine against influenza",

abstract = "An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.",

keywords = "Hemagglutinin (HA), Maternal antibody, Pigs, Replicon particle (RP) vaccine, Swine, Swine influenza virus (SIV)",

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note = "Funding Information: The project was funded by the Grow Iowa Value Fund and Iowa Pork Board. Appreciation is expressed to Abbie Loynachan, Mark Mogler, Ryan Vander Veen, Andrea Holcombe and Steve Gaul for assistance.",

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doi = "10.1016/j.cimid.2010.05.002",

language = "English",

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T1 - Replicon particle vaccine protects swine against influenza

AU - Bosworth, B.

AU - Erdman, M. M.

AU - Stine, D. L.

AU - Harris, I.

AU - Irwin, C.

AU - Jens, M.

AU - Loynachan, A.

AU - Kamrud, K.

AU - Harris, D. L.

N1 - Funding Information: The project was funded by the Grow Iowa Value Fund and Iowa Pork Board. Appreciation is expressed to Abbie Loynachan, Mark Mogler, Ryan Vander Veen, Andrea Holcombe and Steve Gaul for assistance.

PY - 2010/12

Y1 - 2010/12

N2 - An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.

AB - An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.

KW - Hemagglutinin (HA)

KW - Maternal antibody

KW - Pigs

KW - Replicon particle (RP) vaccine

KW - Swine

KW - Swine influenza virus (SIV)

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JO - Comparative Immunology, Microbiology and Infectious Diseases

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Replicon particle vaccine protects swine against influenza

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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