Replicon particle vaccine protects swine against influenza

B. Bosworth, M. M. Erdman, D. L. Stine, I. Harris, C. Irwin, M. Jens, A. Loynachan, K. Kamrud, D. L. Harris

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.

Original languageEnglish
Pages (from-to)e99-e103
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume33
Issue number6
DOIs
StatePublished - Dec 2010

Bibliographical note

Funding Information:
The project was funded by the Grow Iowa Value Fund and Iowa Pork Board. Appreciation is expressed to Abbie Loynachan, Mark Mogler, Ryan Vander Veen, Andrea Holcombe and Steve Gaul for assistance.

Keywords

  • Hemagglutinin (HA)
  • Maternal antibody
  • Pigs
  • Replicon particle (RP) vaccine
  • Swine
  • Swine influenza virus (SIV)

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • General Veterinary
  • Infectious Diseases

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