Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation

Curt D. Sigmund, Robert M. Carey, Lawrence J. Appel, Donna K. Arnett, Hayden B. Bosworth, William C. Cushman, Zorina S. Galis, Melissa Green Parker, John E. Hall, David G. Harrison, Alicia A. McDonough, Holly L. Nicastro, Suzanne Oparil, John W. Osborn, Mohan K. Raizada, Jacqueline D. Wright, Young S. Oh

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The National Heart, Lung, and Blood Institute convened a multidisciplinary working group of hypertension researchers on December 6 to 7, 2018, in Bethesda, MD, to share current scientific knowledge in hypertension and to identify barriers to translation of basic into clinical science/trials and implementation of clinical science into clinical care of patients with hypertension. The goals of the working group were (1) to provide an overview of recent discoveries that may be ready for testing in preclinical and clinical studies; (2) to identify gaps in knowledge that impede translation; (3) to highlight the most promising scientific areas in which to pursue translation; (4) to identify key challenges and barriers for moving basic science discoveries into translation, clinical studies, and trials; and (5) to identify roadblocks for effective dissemination and implementation of basic and clinical science in real-world settings. The working group addressed issues that were responsive to many of the objectives of the National Heart, Lung, and Blood Institute Strategic Vision. The working group identified major barriers and opportunities for translating research to improved control of hypertension. This review summarizes the discussion and recommendations of the working group.

Original languageEnglish
Pages (from-to)902-917
Number of pages16
Issue number4
StatePublished - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.


  • clinical trial
  • goals
  • immunology
  • knowledge
  • science

ASJC Scopus subject areas

  • Internal Medicine


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