Reporting data from high-throughput screening of small-molecule libraries

James Inglese; Caroline E. Shamu; R. Kiplin Guy

doi:10.1038/nchembio0807-438

Reporting data from high-throughput screening of small-molecule libraries

James Inglese, Caroline E. Shamu, R. Kiplin Guy

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

Original language	English
Pages (from-to)	438-441
Number of pages	4
Journal	Nature Chemical Biology
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/nchembio0807-438
State	Published - Aug 2007

Bibliographical note

Funding Information:
The?authors?are?supported?by?the?US?National? Institutes?of?Health?(NIH)?Roadmap?for?Medical? Research?and?the?Intramural?Research?Program?of? the?NIH?National?Human?Genome?Research?Institute? (J.I.),?by?grants?from?the?NIH?(C.E.S.)?and?by?the? American?Lebanese?and?Syrian? Associated?Charities? (ALSAC)?and?St?Jude?Children’s?Research?Hospital? (R.K.G.).

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Reporting data from high-throughput screening of small-molecule libraries",

abstract = "Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.",

author = "James Inglese and Shamu, {Caroline E.} and Guy, {R. Kiplin}",

note = "Funding Information: The?authors?are?supported?by?the?US?National? Institutes?of?Health?(NIH)?Roadmap?for?Medical? Research?and?the?Intramural?Research?Program?of? the?NIH?National?Human?Genome?Research?Institute? (J.I.),?by?grants?from?the?NIH?(C.E.S.)?and?by?the? American?Lebanese?and?Syrian? Associated?Charities? (ALSAC)?and?St?Jude?Children{\textquoteright}s?Research?Hospital? (R.K.G.).",

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AU - Shamu, Caroline E.

AU - Guy, R. Kiplin

N1 - Funding Information: The?authors?are?supported?by?the?US?National? Institutes?of?Health?(NIH)?Roadmap?for?Medical? Research?and?the?Intramural?Research?Program?of? the?NIH?National?Human?Genome?Research?Institute? (J.I.),?by?grants?from?the?NIH?(C.E.S.)?and?by?the? American?Lebanese?and?Syrian? Associated?Charities? (ALSAC)?and?St?Jude?Children’s?Research?Hospital? (R.K.G.).

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AB - Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

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Reporting data from high-throughput screening of small-molecule libraries

Abstract

Bibliographical note

ASJC Scopus subject areas

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