Reprint of "Drawing breath without the command of effectors: The control of respiration following spinal cord injury"

Philippa M. Warren, Basem I. Awad, Warren J. Alilain

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The maintenance of blood gas and pH homeostasis is essential to life. As such breathing, and the mechanisms which control ventilation, must be tightly regulated yet highly plastic and dynamic. However, injury to the spinal cord prevents the medullary areas which control respiration from connecting to respiratory effectors and feedback mechanisms below the level of the lesion. This trauma typically leads to severe and permanent functional deficits in the respiratory motor system. However, endogenous mechanisms of plasticity occur following spinal cord injury to facilitate respiration and help recover pulmonary ventilation. These mechanisms include the activation of spared or latent pathways, endogenous sprouting or synaptogenesis, and the possible formation of new respiratory control centres. Acting in combination, these processes provide a means to facilitate respiratory support following spinal cord trauma. However, they are by no means sufficient to return pulmonary function to pre-injury levels. A major challenge in the study of spinal cord injury is to understand and enhance the systems of endogenous plasticity which arise to facilitate respiration to mediate effective treatments for pulmonary dysfunction.

Original languageEnglish
Pages (from-to)120-130
Number of pages11
JournalRespiratory Physiology and Neurobiology
StatePublished - Dec 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.All rights reserved.

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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